Estudos Randomizados

Estudo randomizado | Nivolumabe vs. nivolumabe com docetaxel para câncer de pulmão de não pequenas células avançado ou recorrente não previamente tratado com imunoterápicos.

29 Ago, 2022 | 16:50h

A randomized comparison of nivolumab versus nivolumab + docetaxel for previously treated advanced or recurrent ICI-naïve non-small-cell lung cancer: TORG1630 – Clinical Cancer Research

 

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Estudo randomizado | Em mulheres sob risco de parto prematuro, metade da dose antenatal de dexametasona NÃO foi não inferior à dose plena em relação aos desfechos neonatais.

29 Ago, 2022 | 16:47h

Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial – The Lancet (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

On 50th anniversary of Liggins & Howie's discovery of benefits of antenatal steroids for preterm birth, new study in @TheLancet confirms full dose (11.4 mg x 2) of betamethasone is necessary for optimum benefit. https://t.co/VgjtprM0W8#neoTwitter #obstetrics @EBNEO @ESPR_EBN pic.twitter.com/Cl1GbzWoRl

— Atul Malhotra (@Atul_Monash) August 19, 2022

 

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Resultados de longo prazo de um estudo randomizado | Vasopressina e metilprednisolona não melhoraram os desfechos em pacientes com parada cardíaca em ambiente hospitalar.

29 Ago, 2022 | 16:40h

Effect of vasopressin and methylprednisolone vs. placebo on long-term outcomes in patients with in-hospital cardiac arrest a randomized clinical trial – Resuscitation

Estudo original: RCT: Vasopressin + Methylprednisolone increase the likelihood of return of spontaneous circulation compared to placebo in patients with in-hospital cardiac arrest.

 

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Estudo randomizado por cluster | Efeito de distribuições bianuais em massa de azitromicina para crianças em idade pré-escolar sobre a prevalência de tracoma.

29 Ago, 2022 | 15:52h

Effect of Biannual Mass Azithromycin Distributions to Preschool-Aged Children on Trachoma Prevalence in Niger: A Cluster Randomized Clinical Trial – JAMA Network Open

 

Comentário no Twitter

Cluster-randomized trial in trachoma-hypoendemic region of Niger mass azithromycin distributions targeted to pre-school children did not reduce trachoma. #OAResearch https://t.co/G7rfZShdz7 pic.twitter.com/UGUlc0x8G8

— JAMA Network Open (@JAMANetworkOpen) August 23, 2022

 

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Seguimento de longo prazo de um estudo randomizado | Lesões de colo do útero pré-cancerosas, causadas por tipos de HPV não preveníveis por vacina, após uso de vacina contra HPV bivalente AS04.

29 Ago, 2022 | 15:50h

Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial – The Lancet Oncology (link para o resumo – $ para o texto completo)

Comentário: Clinical Unmasking May Cause Increased Rates of High-Grade Cervical Neoplasia From Non–Vaccine Preventable HPV – Cancer Network

 

Comentário no Twitter

Virological replacement & clinical unmasking are two phenomena of interest following #HPVvaccination. We show that clinical unmasking might attenuate long-term reductions in cervical precancer following successful implementation of HPV vax programs in highly screened populations https://t.co/Z7dGQNG1kG

— Monica Sierra (@MonicaSSierra) June 14, 2022

 

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Estudo randomizado | Eficácia do ubrogepante no tratamento agudo da enxaqueca com dor leve vs. dor moderada ou grave.

29 Ago, 2022 | 15:48h

Efficacy of Ubrogepant in the Acute Treatment of Migraine With Mild Pain Versus Moderate or Severe Pain – Neurology

 

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Estudo randomizado | Tratamento com mepolizumabe interrompido vs. continuado por longo prazo na asma eosinofílica grave.

29 Ago, 2022 | 13:44h

Stopping versus continuing long-term mepolizumab treatment in severe eosinophilic asthma (COMET study) – European Respiratory Journal

Comentário: Exacerbations Increased After Discontinuing Long-term Use of Mepolizumab for Severe Eosinophilic Asthma – Consultant 360

 

Comentário no Twitter

This randomised study demonstrates increased exacerbation risk and a decrease in asthma control in patients with severe eosinophilic asthma who stop mepolizumab treatment after long-term use, when compared with those who continue treatment. https://t.co/HYCH0TsU9E pic.twitter.com/rW6hmHgJlj

— ERS publications (@ERSpublications) January 6, 2022

 

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Estudo randomizado | Efetividade de uma intervenção para reduzir o tempo sentado e melhorar a saúde em profissionais de escritórios.

23 Ago, 2022 | 17:14h

Effectiveness of an intervention for reducing sitting time and improving health in office workers: three arm cluster randomised controlled trial – The BMJ

Editorial: The importance of sitting less and moving more – The BMJ

Comunicado de imprensa: Standing desks alongside other measures cut office workers’ sitting time by an hour a day – BMJ Newsroom

Comentário: SMART Work and Life Intervention Reduces Sitting Time for Office Workers – HealthDay

 

Comentário no Twitter

Using a standing desk alongside a package of other measures to encourage office workers to sit less and move more, reduced sitting time by about an hour a day over one year, finds a trial published in @bmj_latest today https://t.co/uxaDWnp5WB

— The BMJ (@bmj_latest) August 18, 2022

 

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Estudo randomizado | Sling sintético vs. esfíncter urinário artificial para homens com incontinência urinária de esforço após cirurgia de próstata.

23 Ago, 2022 | 17:13h

Synthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT – Health Technology Assessment

 

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Estudo randomizado | Reconstrução cirúrgica é superior à reabilitação para pacientes com lesão de ligamento cruzado anterior não aguda com sintomas persistentes de instabilidade.

23 Ago, 2022 | 17:12h

Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial – The Lancet

 

Comentário no Twitter

Surgical reconstruction of non-acute ACL injury with persistent symptoms of instability was superior in comparison with rehabilitation at 18 months (KOOS4 mean difference 7.9 (95% CI 2.5–13.2)): https://t.co/y2taBzHolU pic.twitter.com/n0qW3B6cMv

— Søren T. Skou (@STSkou) August 19, 2022

Sob licença de Creative Commons Attribution (CC BY 4.0)

 

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