Tumores Cerebrais/SNC
Estudo randomizado | Temozolomida adjuvante com ou sem interferon alfa em pacientes com gliomas de alto grau recém-diagnosticados
31 Jan, 2023 | 11:55hComentário: Interferon Alfa Improves Upon Standard Care in High Grade Glioma – Cancer Therapy Advisor
Comentário no Twitter
This phase 3 clinical trial demonstrated interferon alfa + temozolomide prolonged survival time in patients with newly diagnosed high-grade gliomas by median 8 months (18% vs 9% 5yr overall survival), especially with MGMT promoter unmethylated tumors. https://t.co/2yOssnF97G
— JAMA Network Open (@JAMANetworkOpen) January 27, 2023
M-A | Extensão da ressecção tumoral e sobrevida em pacientes pediátricos com gliomas de alto grau.
22 Ago, 2022 | 15:18h
Comentário no Twitter
In this systematic review and meta-analysis of pediatric high-grade gliomas, gross total resection was associated with better overall survival than subtotal resection and biopsy. https://t.co/QpKiDKpYYs
— JAMA Network Open (@JAMANetworkOpen) August 16, 2022
Diretriz ASTRO | Radioterapia para glioma difuso IDH-mutante grau 2 e grau 3.
1 Ago, 2022 | 15:20h
Global Retinoblastoma Outcome Study | Análise baseada em grupos e prospectiva de 4.064 pacientes de 149 países.
18 Jul, 2022 | 12:33hComentário convidado: Retinoblastoma as a lens for correctable disparities worldwide – The Lancet Global Health
Comunicado de imprensa: Children in low-income countries 16 times more likely to die from most common eye cancer – London School of Hygiene & Tropical Medicine
Estudo randomizado de fase 2 | Irradiação craniospinal de prótons vs. radioterapia de campo envolvido de fótons para pacientes com metástase leptomeníngea de tumor sólido.
14 Jul, 2022 | 11:30hRandomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis – Journal of Clinical Oncology (link para o resumo – $ para texto completo)
Estudo de braço único fase 1 | Vírus DNX-2401 oncolítico para glioma pontino intrínseco difuso pediátrico.
5 Jul, 2022 | 11:25hOncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentário: Oncolytic Virus Infusion Promising as Brain-Stem Glioma Treatment — Phase I trial shows encouraging OS in children with diffuse intrinsic pontine glioma – MedPage Today (necessário cadastro gratuito)
M-A | Radiocirurgia estereotáxica vs. radioterapia cerebral total em pacientes com doença metastática intracraniana e câncer de pulmão de pequenas células.
31 Mai, 2022 | 11:52hStereotactic radiosurgery versus whole brain radiotherapy in patients with intracranial metastatic disease and small-cell lung cancer: a systematic review and meta-analysis – The Lancet Oncology (link para o resumo – $ para o texto completo)
Comunicado de imprensa: Meta-Analysis Shows Targeted Radiation Therapy May Be as Effective as Standard Care for Small Cell Lung Cancer Patients with Brain Metastases – St. Michael’s Hospital
Estudo de coorte | Efeito da craniotomia com paciente acordado no glioblastoma em áreas de fala.
24 Mai, 2022 | 11:20hEffect of awake craniotomy in glioblastoma in eloquent areas (GLIOMAP): a propensity score-matched analysis of an international, multicentre, cohort study – the Lancet Oncology (link para o resumo – $ para o texto completo)
Comentário: Neurologic and Survival Outcomes After Awake Craniotomy for Glioblastoma – The ASCO Post
Comentário no Twitter
In matched cohort of patients with glioblastoma, awake craniotomy resulted in fewer neurological deficits at 3 mo and 6 mo post-surgery than asleep resection, and longer mOS (17.0 mo versus 14.0 mo; P =0.0005), and mPFS (9.0 mo versus 7.3 mo; P = 0.006) https://t.co/S1fdRTxYDg
— NatureRevClinOncol (@NatRevClinOncol) May 19, 2022
Estudo randomizado | Tratamento com etirinotecano pegol para pacientes com câncer de mama metastático e metástases cerebrais.
16 Mai, 2022 | 16:21hTreatment With Etirinotecan Pegol for Patients With Metastatic Breast Cancer and Brain Metastases: Final Results From the Phase 3 ATTAIN Randomized Clinical Trial – JAMA Oncology (gratuito por tempo limitado)
Comentário no Twitter
Treatment with etirinotecan pegol showed no statistically significant improvement in survival among patients with #BreastCancer & brain metastases, but study represents larged published study for this understudied population. https://t.co/AVKeo1BWQV #BCSM #BTSM
— JAMA Oncology (@JAMAOnc) May 12, 2022
Diretriz ASTRO | Radioterapia para metástases cerebrais.
13 Mai, 2022 | 12:48hComunicado de imprensa: ASTRO issues clinical guideline on radiation therapy for brain metastases – American Society for Radiation Oncology
Comentário no Twitter
ASTRO has released a guideline on #RadiationTherapy for brain metastases, which updates the original 2012 guideline. The publication in #PracticalRO includes treatment algorithms for limited & extensive brain metastases. Read here: https://t.co/5QRI0XqWHx #RadOnc pic.twitter.com/oNj2nzAKdm
— ASTRO (@ASTRO_org) May 10, 2022