Estudos Randomizados
Estudo randomizado | Mepolizumabe para crianças urbanas com asma eosinofílica propensas a exacerbação.
23 Ago, 2022 | 17:03hMepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial – The Lancet (link para o resumo – $ para o texto completo)
Comentário: Mepolizumab Cuts Exacerbations in Children With Severe Asthma – HealthDay
Estudo randomizado | Efetividade da terapia com etoposídeo e cisplatina vs. irinotecano e cisplatina para pacientes com carcinoma neuroendócrino avançado do sistema digestório.
23 Ago, 2022 | 16:33h
Comentário no Twitter
JCOG1213 (TOPIC NEC), the first randomized phase III trial in advanced neuroendocrine carcinoma of the digestive system, shows no significant difference in overall survival for etoposide+cisplatin versus irinotecan+cisplatin therapy https://t.co/JTELRlzTzi #GICSM pic.twitter.com/AQT8U4yd3l
— JAMA Oncology (@JAMAOnc) August 18, 2022
Estudo randomizado | Transplante de microbiota fecal com dieta anti-inflamatória reduziu e manteve a remissão em um pequeno estudo de pacientes com colite ulcerativa leve a moderada.
23 Ago, 2022 | 16:10hFaecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial – Gut (link para o resumo – $ para o texto completo)
Comentário: Fecal Transplant With Anti-Inflammatory Diet Yields Remissions in UC – MedPage Today (necessário cadastro gratuito)
Estudo randomizado | Critério glicêmico mais baixo não é melhor do que um critério de glicemia mais alta para diagnóstico de diabetes gestacional.
22 Ago, 2022 | 16:46hLower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentário: Pros and cons with lower vs higher threshold for gestational diabetes diagnosis – medwire News
Comentário no Twitter (fio – clique para saber mais)
1/ Overdiagnosis of Gestational Diabetes (GDM): New large randomized trial compared broader/narrower criteria -> NO improvement in mother/baby outcomes BUT x2 increase in % pregnant women labelled as GDM. Time to reconsider GDM testing – https://t.co/xrr0XrdhaZ
— Paul Glasziou (@PaulGlasziou) August 18, 2022
Estudo randomizado | Metformina, ivermectina e fluvoxamina não são benéficas para pacientes ambulatoriais obesos com Covid-19.
22 Ago, 2022 | 16:44hEditorial: Time to Stop Using Ineffective Covid-19 Drugs – New England Journal of Medicine
Comentário no Twitter
In this trial involving overweight or obese outpatients with Covid-19, investigators found that none of three repurposed drugs (metformin, ivermectin, and fluvoxamine) reduced the risk of serious disease. https://t.co/8sd6R7CDK6 pic.twitter.com/bPZ6zeuZSA
— NEJM (@NEJM) August 17, 2022
Estudo randomizado | Efetividade de um programa de treinamento de exercícios domiciliar de longo prazo em pacientes com DPOC após reabilitação pulmonar.
22 Ago, 2022 | 16:31h
Comentário no Twitter
Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation: A multi-center randomized controlled trialhttps://t.co/8u1nizaDNq pic.twitter.com/QwqzN1dDHK
— Physio Meets Science (@PhysioMeScience) August 17, 2022
Sob licença de Creative Commons
Estudo randomizado | Ceftolozano/tazobactam com metronidazol vs. meropeném em pacientes com infecções intra-abdominais complicadas.
22 Ago, 2022 | 16:26h
Estudo randomizado | Efeito do condicionamento isquêmico remoto vs. cuidado usual da função neurológica de pacientes com AVC isquêmico agudo moderado.
22 Ago, 2022 | 16:10hEffect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial – JAMA (gratuito por tempo limitado)
Editorial: Remote Ischemic Conditioning: Feasible and Potentially Beneficial for Ischemic Stroke – JAMA (gratuito por tempo limitado)
Resumo em vídeo: Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke – JAMA
Estudo randomizado | TC torácica com radiografia vs. radiografia torácica para seguimento de câncer de pulmão de não pequenas células completamente ressecado.
22 Ago, 2022 | 14:56hChest CT scan plus x-ray versus chest x-ray for the follow-up of completely resected non-small-cell lung cancer (IFCT-0302): a multicentre, open-label, randomised, phase 3 trial – The Lancet Oncology (link para o resumo – $ para o texto completo)
Comentário no Twitter (fio – clique para saber mais)
Totally unexpected! After resection of early NSCLC in 1775 pts, follow-up by ct-scan did not improve survival vs a simple chest X-Rays! We should ALWAYS questioned our practice. Amazing work from Virginie Westeel @barlesi @IFCTlung https://t.co/iMFGtpkQcF
— Benjamin Besse (@BenjaminBesseMD) August 12, 2022
Estudo randomizado | Exposição e prevenção de resposta via internet com apoio terapêutico para crianças e adolescentes com síndrome de Tourette.
22 Ago, 2022 | 14:35hComentários:
Online Exposure Therapy Improves Tic Symptoms in Youth – Psychiatric News Alert
Comentário no Twitter
In this RCT, 221 youths with #Tourette syndrome or chronic tic disorder received therapist-supported, internet-delivered exposure and response prevention (ERP) or education. Both groups improved over time, with no between-group differences in tic severity. https://t.co/YND2mgPn2Q
— JAMA Network Open (@JAMANetworkOpen) August 15, 2022