Outras notícias
Causas do câncer hepático estão mudando ao redor do mundo: algumas ganham força, outras perdem.
19 Jun, 2022 | 13:17hComunicado de imprensa: Causes of Liver Cancer are Changing Around the World: Some Up, Some Down – UC San Diego Health
Estudo original: Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer – Cell Metabolism (link para o resumo – $ para o texto completo)
Inibidor de SGLT2 reduz o risco de hiperpotassemia em pacientes com insuficiência cardíaca.
19 Jun, 2022 | 13:15hEditorial: Emerging role for SGLT2 inhibitors in mitigating the risk of hyperkalaemia in heart failure
Conteúdo relacionado: Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial – European Heart Journal
Comentário no Twitter
More evidence that SGLT2i ⬇️ hyperK, this time in heart failure
Empagliflozin reduces:
– K>6.0: HR 0.62 95% CI 0.48–0.81
– Investigator reported hyperK or K binders, HR 0.82 95% CI 0.71-0.95
– Effect modified by GFR – larger in CKD
– Regardless of MRAshttps://t.co/t4T7II1G8p pic.twitter.com/RP1EUKXHyV— Brendon Neuen (@brendonneuen) June 12, 2022
Sob a licença de https://creativecommons.org/licenses/by-nc/4.0/
Análise de especialista | Tratamento da pericardite na gestação.
19 Jun, 2022 | 13:13hPericarditis Management in Pregnancy – American College of Cardiology
Estudo | Maioria dos homens que morrem em decorrência de suicídio não tinham nenhuma condição de saúde mental conhecida.
19 Jun, 2022 | 13:12hComentário: Most Males Who Die by Suicide Have No Known Mental Health Condition – Psychiatric News Alert
Estudo original: Suicide Among Males Across the Lifespan: An Analysis of Differences by Known Mental Health Status – American Journal of Preventive Medicine
Estudo de coorte | Desfechos de longo prazo com o uso precoce de antipsicóticos injetáveis de ação prolongada na esquizofrenia.
19 Jun, 2022 | 13:10hLong-term Outcomes of Early Use of Long-Acting Injectable Antipsychotics in Schizophrenia – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Conteúdos relacionados:
Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link para o resumo – $ para o texto completo)
Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry (link para o resumo – $ para o texto completo)
Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry (link para o resumo – $ para o texto completo)
Imunoterapia direcionada ao hospedeiro para infecções virais e bacterianas: passado, presente e futuro.
19 Jun, 2022 | 13:07hHost-directed immunotherapy of viral and bacterial infections: past, present and future – Nature Reviews Immunology (se o acesso a este link for pago, tente este no PMC)
Comentário no Twitter
A Perspective in @NatRevImmunol reflects on the historical development of host-directed immunotherapeutic interventions for infections and how historical insights can be used in the therapy of SARS-CoV-2 and Mycobacterium tuberculosis infections. https://t.co/5WOXzePpFS pic.twitter.com/dpj1XNi2me
— Nature Portfolio (@NaturePortfolio) June 11, 2022
Relatos de caso | Terapia com talidomida em 18 pacientes com malformação arteriovenosa grave.
19 Jun, 2022 | 13:06hCase report study of thalidomide therapy in 18 patients with severe arteriovenous malformations – Nature Cardiovascular Research (link para o resumo – $ para o texto completo)
Revisão sistemática | Oxicodona para dor relacionada a câncer.
19 Jun, 2022 | 13:05hOxycodone for cancer‐related pain – Cochrane Library
Resumo: Oxycodone for cancer-related pain in adults – Cochrane Library
DNA circulante de tumor e recorrência tardia em câncer de mama de alto risco, positivo para receptor de hormônio e negativo para receptor do fator de crescimento epidérmico humano 2.
19 Jun, 2022 | 13:04hComentário: Tumor DNA Assay Portends Metastatic Breast Cancer Recurrence Months in Advance — First evidence for patients in late adjuvant setting, years after initial diagnosis – MedPage Today (necessário cadastro gratuito)
Comentário no Twitter
103 women in long-term remission from high-risk HR+/HER2- breast cancer had customized monitoring of recurrence based on ctDNA seq for tumour-associated mut. Among 8 pts MRD+ pts, 6 developed distant recurrence at a median 12.4 mo after ctDNA positivity https://t.co/aX1ruLCSbb
— NatureRevClinOncol (@NatRevClinOncol) June 9, 2022
Seguimento de 2 anos de estudo de braço único | Ciltacabtageno Autoleucel, uma terapia de células T do receptor de antígeno quimérico anticélula B de maturação, para mieloma múltiplo recorrente/refratário.
19 Jun, 2022 | 13:02hEstudo original: Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study – The Lancet (link para o resumo – $ para o texto completo)
Comentário no Twitter
In follow-up from CARTITUDE-1 trial of ciltacabtagene autoleucel in R/R MM, ORR was 97.9% and 82.5% had a stringent CR. 27-mo PFS was 54% and OS was 70.4% https://t.co/cnpzkg5yKM
— NatureRevClinOncol (@NatRevClinOncol) June 9, 2022