Acesso livre
Acesso livre

Hematologia

Terapia genética com valoctocogene roxaparvovec para hemofilia A.

22 Mar, 2022 | 11:28h

Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentários:

Valoctocogene Roxaparvovec Evaluated in Severe Hemophilia A – HealthDay

Hemophilia A Gene Therapy Reduced Bleeding Events, Need for Clotting Factors – AJMC

Estudo randomizado de fase 2 | Consolidação com venetoclax após duração fixa de venetoclax com obinutuzumabe para leucemia linfocítica crônica sem tratamento prévio.

22 Mar, 2022 | 11:23h

Venetoclax consolidation after fixed-duration venetoclax plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (HOVON 139/GiVe): primary endpoint analysis of a multicentre, open-label, randomised, parallel-group, phase 2 trial – The Lancet Haematology (link para o resumo – $ para o texto completo)

Comentário: #VisualAbstract Venetoclax consolidation after fixed-duration venetoclax plus obinutuzumab treatment does not show added activity in chronic lymphocytic leukaemia – Physician’s Weekly

 

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Diretriz | Manejo de anticoagulantes e antiplaquetários durante sangramento gastrintestinal agudo e período periendoscópico.

21 Mar, 2022 | 16:38h

American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period – Journal of the Canadian Association of Gastroenterology

 

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Estudo randomizado | Eficácia de plinabulina vs. pegfilgrastima para prevenir neutropenia induzida por docetaxel em pacientes com tumores de órgãos sólidos.

21 Mar, 2022 | 16:01h

Efficacy of Plinabulin vs Pegfilgrastim for Prevention of Docetaxel-Induced Neutropenia in Patients With Solid Tumors: A Randomized Clinical Trial – JAMA Network Open

 

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Estudo randomizado | Bortezomibe em leucemia linfoblástica aguda e linfoma de células T recém-diagnosticados.

21 Mar, 2022 | 15:56h

Children’s Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)

Comentário: New study finds bortezomib improves survival in children with newly diagnosed T-cell lymphoblastic lymphoma – Children’s Hospital of Philadelphia

Recomendações do consenso de especialistas sobre o diagnóstico e o tratamento da histiocitose de células de Langerhans em adultos.

17 Mar, 2022 | 12:59h

Expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults – Blood

Visão geral da ressuscitação no trauma e complicações de transfusão.

17 Mar, 2022 | 12:39h

Happy TRALIdays: An Overview of Trauma Resuscitation and Transfusion Complications – emDocs

Diretriz NCCN | Linfomas de células T.

15 Mar, 2022 | 13:10h

T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

Metanálise de estudos randomizados comparando estratégias de transfusão de hemácias intraoperatória.

14 Mar, 2022 | 14:07h

A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies – Annals of Surgery

Conteúdos relacionados:

Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

Meta-Analysis: Effects of Restrictive vs. Liberal Transfusion Strategies on Longer-term Outcomes After Cardiac Surgery

Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury

Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care

Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA

Metanálise de estudos randomizados | Benefícios e prejuízos de anticoagulantes orais diretos e da heparina de baixo peso molecular para a tromboprofilaxia de pacientes submetidos a cirurgia não cardíaca.

10 Mar, 2022 | 15:52h

Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials – The BMJ

 

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