Estudos Randomizados
Perspectiva | Pragmatismo em estudos clínicos: essencial, não opcional.
16 Ago, 2022 | 12:55hPragmatism in clinical trials: essential, not optional – European Journal of Cardiology (gratuito por tempo limitado)
Comentário no Twitter
A call for pragmatism in the design and running of clinical trials:https://t.co/bXQ4Wp0x1i#EHJ@escardio pic.twitter.com/ES1X12zTGv
— EHJ Editor-in-Chief (@ehj_ed) August 11, 2022
Estudo randomizado | Omecamtiv Mecarbil não melhora a capacidade de exercício na insuficiência cardíaca com fração de ejeção reduzida.
16 Ago, 2022 | 12:49hEffect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial – JAMA (link para o resumo – $ para o texto completo)
Entrevista com os autores: Can Omecamtiv Mecarbil Improve Peak Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)? – JAMA
Comentários:
Omecamtiv Mecarbil Fails to Improve Exercise Capacity in HFrEF – Medscape (necessário cadastro gratuito)
Conteúdo relacionado: #AHA20 – Randomized trial: In patients with systolic heart failure, Cardiac Myosin activation with Omecamtiv Mecarbil led to modest reduction in heart failure events
Comentário no Twitter
#OriginalInvestigation: Multicenter randomized clinical trial found that, in patients with chronic #HFrEF, omecamtiv mecarbil did not significantly improve exercise capacity over 20 weeks compared with placebo. @GLewisCardiol https://t.co/f27Y0oya6S
— JAMA (@JAMA_current) July 20, 2022
Estudo randomizado | Secuquinumabe na artrite relacionada a entesite e na artrite psoriática juvenil.
16 Ago, 2022 | 12:47h
Estudo randomizado | Pequeno estudo sugere que morfina intraóssea pode reduzir a dor pós-operatória e o uso de medicações analgésicas após artroplastia total de joelho.
16 Ago, 2022 | 12:46hComunicado de imprensa: A new way to control pain after knee replacement surgery – Houston Methodist
Estudo randomizado | Um pequeno estudo avaliou a segurança e a eficácia do levetiracetam profilático para prevenção de convulsões epilépticas na fase aguda da hemorragia intracerebral.
16 Ago, 2022 | 12:45hSafety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Neurology (link para o resumo – $ para o texto completo)
Comentário no Twitter (fio – clique para saber mais)
Small study that is not powered to answer this question but raises an interesting ❓ nonetheless: should we use prophylactic antiseizure 💊in #ich? Most recently updated guidelines recommend against this practice. https://t.co/NH45OCtzvv
— Richard Choi, DO (@rkchoi) August 11, 2022
Estudo randomizado | Remoção de cálculos renais pequenos e assintomáticos e incidência de recorrência.
12 Ago, 2022 | 18:15hRemoval of Small, Asymptomatic Kidney Stones and Incidence of Relapse – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentário no Twitter
Removal of small, asymptomatic kidney stones during surgery to remove ureteral or contralateral stones resulted in less relapse than nonremoval and in similar numbers of subsequent emergency department visits. https://t.co/MRgFUnF1C0 pic.twitter.com/19ahPuHyNS
— NEJM (@NEJM) August 10, 2022
Estudo randomizado | Em pacientes idosos submetidos a anestesia intravenosa total, o etomidato é não inferior ao propofol em relação ao risco de complicações pós-operatórias maiores.
12 Ago, 2022 | 18:10h
Comentário no Twitter
General anesthesia with etomidate does not increase postoperative morbidity, as indicated by the rate of major in-hospital post-op complications, in elderly patients undergoing abdominal surgery, as compared with propofol. https://t.co/vjPvle3DQj pic.twitter.com/2k6eSLupbH
— JAMA Surgery (@JAMASurgery) August 10, 2022
Estudo randomizado | Solução inalatória de tobramicina é efetiva em adultos com bronquiectasia e infecção por Pseudomonas aeruginosa.
12 Ago, 2022 | 18:08hComentário: Tobramycin Tames Infection in Bronchiectasis – Medscape (necessário cadastro gratuito)
Estudo relacionado: Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial – Thorax
Estudo randomizado | Efeito de dexmedetomidina versus midazolam intranasal para pré-medicação em casos de eventos adversos respiratórios em crianças submetidas a tonsilectomia e adenoidectomia.
12 Ago, 2022 | 18:02hComentários:
Dexmedetomidine Cuts Perioperative Respiratory AEs in Tonsillectomy – HealthDay
Comentário no Twitter
Children often required sedatives before surgery due to anxiety and crying. In this RCT, intranasal midazolam increased the incidence of perioperative respiratory adverse events (PRAEs), while intranasal dexmedetomidine reduced PRAEs. #OrigInvestigation https://t.co/5AAILuzstM pic.twitter.com/WejpGkAGGs
— JAMA Network Open (@JAMANetworkOpen) August 9, 2022
Estudo randomizado | Decitabina em baixa dose vs. azacitidina em baixa dose nas síndromes mielodisplásicas de baixo risco.
12 Ago, 2022 | 17:58hLow-Dose Decitabine versus Low-Dose Azacitidine in Lower-Risk MDS – NEJM Evidence
Comentário no Twitter
Low dose hypomethylating agent therapy led to an overall response rate of 60% in pts with low- or intermediate-risk myelodysplastic syndromes or chronic myelomonocytic leukemia who had not received prior hypomethylating agents. https://t.co/OSpNLzfiKW#MDS #LeuSM #CMML pic.twitter.com/BN1XAhfUBo
— NEJM Evidence (@NEJMEvidence) August 9, 2022