Estudos Randomizados

Estudo randomizado | Tratamento tópico do edema macular diabético com uso de suspensão oftálmica de dexametasona.

12 Ago, 2022 | 17:54h

Topical treatment of diabetic macular edema using dexamethasone ophthalmic suspension: A randomized, double-masked, vehicle-controlled study – Acta Ophthalmologica

Comentário: Topical Dexamethasone Ophthalmic Suspension OCS-01 Effective in DME Treatment – HCP Live

Estudo randomizado | Analgesia epidural torácica vs. analgesia por cateter na bainha do músculo reto do abdomen após cirurgia abdominal maior aberta de linha média.

12 Ago, 2022 | 17:24h

A comparison between thoracic epidural analgesia and rectus sheath catheter analgesia after open midline major abdominal surgery: randomized clinical trial – BJS Open

Estudo randomizado | Fechamento abdominal Hughes vs. fechamento de padrão para reduzir hérnias incisionais após cirurgia de câncer colorretal.

10 Ago, 2022 | 14:39h

Hughes abdominal closure versus standard mass closure to reduce incisional hernias following surgery for colorectal cancer: the HART RCT – Health Technology Assessment

Estudo randomizado | Doses de radiação e esquemas de fracionamento no carcinoma ductal in situ mamário de não baixo risco.

10 Ago, 2022 | 14:28h

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study – The Lancet (link para o resumo – $ para o texto completo)

Estudo randomizado | Efeito de um intervenção abrangente de telemedicina vs. telemonitoramento e coordenação de cuidados em pacientes com diabetes tipo 2 de controle persistentemente ruim.

10 Ago, 2022 | 14:26h

Effect of a Comprehensive Telehealth Intervention vs Telemonitoring and Care Coordination in Patients With Persistently Poor Type 2 Diabetes Control: A Randomized Clinical Trial – JAMA Internal Medicine (link para o resumo – $ para o texto completo)

Comentário: Comprehensive telehealth intervention effective for reducing HbA1c in poorly controlled diabetes – Physician’s Weekly

Comentário no Twitter

A comprehensive telehealth intervention improved HbA1c in persistently poorly-controlled type 2 diabetes compared to a simpler telehealth intervention; the comprehensive telehealth approach may warrant implementation in systems with appropriate resources. https://t.co/qXnuclyipQ

— JAMA Internal Medicine (@JAMAInternalMed) July 29, 2022

Estudo randomizado | Eficácia e segurança de paracetamol intravenoso (2 g/dia) para redução do consumo de opioides em adultos chineses após cirurgia ortopédica eletiva.

10 Ago, 2022 | 14:21h

Efficacy and safety of intravenous acetaminophen (2 g/day) for reducing opioid consumption in Chinese adults after elective orthopedic surgery: A multicenter randomized controlled trial – Frontiers in Pharmacology

Estudo randomizado | Efetividade da vareniclina e da cistina para redução do uso de álcool entre pessoas com HIV e em uso de substâncias.

10 Ago, 2022 | 14:19h

Effectiveness of Varenicline and Cytisine for Alcohol Use Reduction Among People With HIV and Substance Use: A Randomized Clinical Trial – JAMA Network Open

Comentário: Varenicline and cytisine not more efficacious than nicotine to treat risky drinking and smoking, study says – News Medical / Vanderbilt University Medical Center

Comentário no Twitter

In this RCT, varenicline and cytisine were not more efficacious than nicotine to treat risky drinking and smoking among individuals with HIV; rates of behavior change for alcohol consumption and smoking were high in all treatment groups. #OrigInvestigation https://t.co/h8M6e5nOkf

— JAMA Network Open (@JAMANetworkOpen) August 5, 2022

Dois estudos randomizados mostraram que anticorpos monoclonais não são melhores que placebo para doença de Parkinson.

9 Ago, 2022 | 17:31h

Estudo 1: Trial of Cinpanemab in Early Parkinson’s Disease – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Estudo 2: Trial of Prasinezumab in Early-Stage Parkinson’s Diseas – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentário: Monoclonal Antibodies No Better Than Placebo for Early Parkinson Disease – HealthDay

Estudo randomizado | Estimulação transvenosa e temporária de nervo frênico não é benéfica para pacientes em UTI com desmame difícil.

9 Ago, 2022 | 17:20h

Randomized Clinical Study of Temporary Transvenous Phrenic Nerve Stimulation in Difficult-to-Wean Patients – American Journal of Respiratory and Critical Care Medicine

Editorial: Transvenous Phrenic Nerve Stimulation: A Novel Therapy Gathering Pace – American Journal of Respiratory and Critical Care Medicine

Estudo randomizado | Irradiação mamária parcial vs. total para câncer de mama precoce.

9 Ago, 2022 | 17:16h

Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial – Journal of Clinical Oncology (link para o resumo – $ para o texto completo)