Clínica Médica

Eficácia e segurança do tratamento não cirúrgico da apendicite aguda não complicada em comparação à apendicectomia: uma revisão abrangente de revisões sistemáticas e metanálises.

11 Mar, 2022 | 14:58h

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Conteúdos relacionados:

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

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Revisão | Colecistite aguda.

11 Mar, 2022 | 14:52h

Acute Cholecystitis: A Review – JAMA (gratuito por tempo limitado)

Entrevista com o autor: Acute Cholecystitis

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Associação entre uso de estatinas e eventos adversos musculoesqueléticos relacionados à daptomicina: uma abordagem mista combinando metanálise e análise de desproporcionalidade.

11 Mar, 2022 | 14:50h

Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis – Clinical Infectious Diseases

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Revisão sistemática | Agentes antiplaquetários para doença renal crônica.

11 Mar, 2022 | 14:47h

Antiplatelet agents for chronic kidney disease – Cochrane Library

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Amplo estudo baseado em registro mostrou aumento do risco cardiovascular em pacientes com esquizofrenia, transtorno esquizoafetivo ou transtorno bipolar.

11 Mar, 2022 | 14:42h

Cardiovascular Risk for Patients With and Without Schizophrenia, Schizoaffective Disorder, or Bipolar Disorder – Journal of the American Heart Association

Comentário: Serious mental illness associated with increased cardiovascular risk in young adults – American Heart Association/News Medical

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Metanálise de estudos randomizados | Benefícios e prejuízos de anticoagulantes orais diretos e da heparina de baixo peso molecular para a tromboprofilaxia de pacientes submetidos a cirurgia não cardíaca.

10 Mar, 2022 | 15:52h

Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials – The BMJ

 

Comentário no Twitter

Led by Maura Marcucci, network meta-analysis of of 68 surgery #RCT's (45,445 patients; mainly #ortho) found that #DOAC's & #LMWH reduce #VTE but probably increase major bleeding to a similar extent. DOACs probably prevent symptomatic VTE more than #LMWH. https://t.co/7vrgVpfD3s pic.twitter.com/H5Fuq7p1hi

— Kari Tikkinen (@KariTikkinen) March 9, 2022

 

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Perspectiva | Uma vez visto como um tratamento promissor da COVID-19, o plasma convalescente cai em desuso.

10 Mar, 2022 | 15:49h

Once Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA

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Perspectiva | O que sabemos sobre o impacto da Covid no cérebro?

10 Mar, 2022 | 15:47h

What do we know about Covid’s impact on the brain? – The Guardian

Conteúdo relacionado: SARS-CoV-2 is associated with changes in brain structure in UK Biobank.

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Diretriz | Implementação de diretrizes avançadas no período perioperatório, incluindo planos para ressuscitação cardiopulmonar.

10 Mar, 2022 | 15:41h

Implementing advance care plans in the peri-operative period, including plans for cardiopulmonary resuscitation: Association of Anaesthetists clinical practice guideline – Anaesthesia

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Diretrizes de prática clínica baseada em evidências para a doença do refluxo gastroesofágico.

10 Mar, 2022 | 15:38h

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021 – Journal of Gastroenterology

Conteúdos relacionados:

ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease.

SAGES guidelines for the surgical treatment of gastroesophageal reflux.

Guideline on Screening for Esophageal Adenocarcinoma in Patients with Chronic GERD

NICE Guideline: Gastro-esophageal Reflux Disease and Dyspepsia in Adults

NICE Guideline: Gastroesophageal Reflux Disease in Children and Young People

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