Acesso livre
Acesso livre

Clínica Médica

Revisão | Dor crônica e infecção: mecanismos, causas, condições, tratamentos e controvérsias.

11 Abr, 2022 | 12:51h

Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies – BMJ Medicine

AVC: avanços no tratamento dão esperança ao pacientes.

11 Abr, 2022 | 12:50h

Stroke: advances in treatment offer hope for patients – Evidently Cochrane

Intervenções para tratar infecções de corrente sanguínea relacionadas a cateter em pessoas sob hemodiálise de manutenção.

11 Abr, 2022 | 12:46h

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis – Cochrane Library

Resumo: Interventions for treating catheter-related bloodstream infections in people receiving maintenance haemodialysis – Cochrane Library

Comentário de estudo | De volta ao BaSICS (estudo que comparou solução balanceada com solução salina a 0,9% em pacientes críticos).

11 Abr, 2022 | 12:43h

Back to BaSICS – Annals of Emergency Medicine

Estudos originais:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Conteúdos relacionados:

Perspective: The ongoing saga of normal saline vs. balanced fluids.

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis – NEJM Evidence

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

Aplicações atuais e limitações das diretrizes europeias sobre medidas de pressão arterial: implicações para a prática clínica.

11 Abr, 2022 | 12:34h

Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice – Internal and Emergency Medicine

Conteúdos relacionados:

Randomized Diagnostic Study: home blood pressure measurements correlate better with 24-h ambulatory monitoring measurements compared to clinic, and kiosk measurements.

Practice guidelines for office and out-of-office blood pressure measurement.

Study suggests a 30-second interval between automated office blood pressure measurements is as accurate and reliable as a 60-second interval.

USPSTF Statement recommends screening for hypertension in adults 18 years or older with office blood pressure measurement – diagnostic confirmation with blood pressure measurements outside of the clinical setting is advised before starting treatment

Study suggests that 7 days of home blood pressure monitoring is likely better than 24h ambulatory monitoring or 3 office measurements

Estudo mostra risco aumentado de embolia pulmonar em até 110 dias após a COVID-19.

8 Abr, 2022 | 21:58h

Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study – The BMJ

Comunicado de imprensa: Study finds increased risk of serious blood clots up to six months after COVID-19 – BMJ

Editorial: Thromboembolism and bleeding after covid-19

Comentário: Covid: Blood clot risk higher for six months after having virus – BBC

COVID-19: diretriz conjunta do ECDC e EMA sobre a 4ª dose de vacinas de mRNA.

8 Abr, 2022 | 21:56h

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines –
European Centre for Disease Prevention and Control

Conteúdos relacionados:

Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

Comentário no Twitter (fio – clique para saber mais)

 

Estudo randomizado pragmático | Em pacientes ambulatoriais com COVID-19, a adição da oximetria de pulso para monitoramento não melhorou os desfechos em comparação a avaliações subjetivas isoladas da dispneia.

8 Abr, 2022 | 21:54h

Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial – New England Journal of Medicine

 

Comentário no Twitter

 

M-A | Fluvoxamina no tratamento ambulatorial da COVID-19 para evitar internação.

8 Abr, 2022 | 21:52h

Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis – JAMA Network Open

Comentário: Common Antidepressant Likely Cuts Risk Of Covid Hospitalization, Study Finds – Forbes

Conteúdos relacionados:

Short Review: Fluvoxamine for symptomatic outpatients with COVID-19.

Fluvoxamine for Covid-19: What Prescribers and Pharmacists Need to Know.

Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.

RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Comentário no Twitter

 

Estudo randomizado | Entre pacientes com infecção complicada de trato urinário, o uso oral de tebipenem pivoxil hidrobromida foi não inferior ao ertapenem intravenoso e mostrou perfil de segurança similar.

8 Abr, 2022 | 21:50h

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

 

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