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Clínica Médica

Estudo randomizado | Eficácia de longo prazo e segurança da denervação renal na presença de medicamentos anti-hipertensivos.

8 Abr, 2022 | 21:47h

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial – The Lancet (link para o resumo – $ para o texto completo)

Comentário: Three-year trial of SPYRAL HTN-ON MED shows blood pressure reductions – MedicalXpress

Conteúdos relacionados:

Systematic Review: Renal denervation may have a modest effect in improving 24h ambulatory blood pressure monitoring (reduction in SBP by 5.29 mmHg and DBP by 3.75 mmHg) but does not improve major cardiovascular outcomes and renal function.

M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.

Meta-Analysis: Sham-Controlled Randomized Trials of Catheter-Based Renal Denervation in Patients with Hypertension

 

Comentário no Twitter

 

Perspectiva | Como estudar a COVID longa grave para compreender os distúrbios pós-infecciosos além da COVID-19.

8 Abr, 2022 | 21:42h

Studying severe long COVID to understand post-infectious disorders beyond COVID-19 – Nature Medicine

Conteúdos relacionados:

Review: Post-acute COVID-19 syndrome.

ESCMID rapid guidelines for assessment and management of long COVID.

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (vários artigos sobre o tema)

2022 ACC expert consensus decision pathway on cardiovascular sequelae of COVID-19 in adults: myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play.

Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

 

Comentário do autor no Twitter (fio – clique para saber mais)

 

Grandes queimados – Parte 2 | Anestesia, terapia intensiva e manejo da dor.

8 Abr, 2022 | 21:22h

Major burns: part 2. Anaesthesia, intensive care and pain management – BJA Education

Ver também: Major burns: Part 1. Epidemiology, pathophysiology and initial management.

Consenso de especialistas | Passo a passo da abordagem diagnóstica para pacientes com uveíte.

8 Abr, 2022 | 21:19h

Step-wise diagnostic approach for patients with uveitis – Experts consensus in Taiwan – Journal of Microbiology, Immunology and Infection

Estudo observacional sugere que a 4ª dose da vacina da Pfizer forneceu proteção adicional contra doença grave em pacientes com 60 anos de idade ou mais durante a onda da variante Ômicron em Israel.

8 Abr, 2022 | 21:11h

Protection by a Fourth Dose of BNT162b2 against Omicron in Israel – New England Journal of Medicine

Comentário: Mixed Bag for Fourth Dose of Pfizer Vaccine vs Omicron— Real-world data show less infection and severity, but long-term benefit less clear – MedPage Today (necessário cadastro gratuito)

Conteúdos relacionados:

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

Comentário no Twitter

 

M-A | Risco de recorrência em mulheres com tromboembolismo venoso relacionado ao uso de contraceptivos com estrogênio.

8 Abr, 2022 | 17:28h

Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives: Systematic review and meta-analysis – Journal of Thrombosis and Haemostasis

Tendências globais, regionais e nacionais do consumo de analgésicos opioides de 2015 a 2019.

8 Abr, 2022 | 17:21h

Global, regional, and national trends in opioid analgesic consumption from 2015 to 2019: a longitudinal study – The Lancet Public Health

Comunicado de imprensa: Global disparities persist in opioid painkiller access – University College London

Comentário convidado: Closing the global pain divide: balancing access and excess – The Lancet Public Health

 

Comentário no Twitter (artigo e imagens sob licença de Creative Commons Attribution (CC BY 4.0)

 

Estudo randomizado | Roxadustate oral vs. epoietina alfa no tratamento de anemia em pacientes sob diálise para doença renal crônica.

8 Abr, 2022 | 17:19h

Roxadustat Versus Epoetin Alfa for Treating Anemia in Patients with Chronic Kidney Disease on Dialysis: Results from the Randomized Phase 3 ROCKIES Study – Journal of the American Society of Nephrology

Conteúdos relacionados:

Randomized Trials: Evaluation of New Treatment for Anemia of Chronic Kidney

RCT: Efficacy and safety of Daprodustat (oral drug) for treating anemia of chronic kidney disease in incident dialysis patients.

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

Revisão e M-A | Reabilitação pulmonar pós-Covid.

8 Abr, 2022 | 17:18h

Estudo 1: The effectiveness of pulmonary rehabilitation for Post-COVID symptoms: A rapid review of the literature – Respiratory Medicine

Estudo 2: Effect of Pulmonary Rehabilitation for Patients With Post-COVID-19: A Systematic Review and Meta-Analysis – Frontiers in Medicine

Estudo de coorte e metanálise atualizada | Alto consumo de ovos e de colesterol na dieta está ligado a risco aumentado de mortalidade geral e por doenças cardiovasculares.

8 Abr, 2022 | 17:16h

Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality, and Systematic Review and Updated Meta-Analysis – Circulation

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