Clínica Médica
Estudo randomizado | Para adultos vivendo com HIV, uma estratégia de tratamento de 4-dias-sim e 3-dias-não é não inferior ao tratamento padrão para manter a supressão viral.
12 Abr, 2022 | 12:45hA 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial – The Lancet HIV (link para o resumo – $ para o texto completo)
Comentário: Intermittent Treatment Strategy Is Effective for HIV – Consultant360
Comentário no Twitter
New: A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial by Roland Landman and colleagues https://t.co/Tc2Rbo1ISt pic.twitter.com/YTV3XwfELo
— The Lancet HIV (@TheLancetHIV) February 3, 2022
In virologically suppressed people with HIV, randomization to intermittent ART (4 days on, 3 off) was non-inf. to daily dosing. Challenges what I thought about level of adherence needed. Is good adherence only needed during the viremic phase? https://t.co/lM8QZW0C9h
— David Serota (@serotavirus) March 16, 2022
Revisão | Síndrome gastrintestinal pós-COVID-19 aguda.
12 Abr, 2022 | 12:43hGastrointestinal post-acute COVID-19 syndrome – Nature Reviews Gastroenterology & Hepatology
Comentário no Twitter
NEW! COMMENT
Gastrointestinal post-acute COVID-19 syndromehttps://t.co/SDAOnQSEp4#COVID19 #LongCovid pic.twitter.com/CUSoUt0azy
— Nature Reviews Gastroenterology & Hepatology (@NatRevGastroHep) April 9, 2022
Estudo randomizado | Efeito da antibioticoterapia inicial guiada por coloração de Gram sobre a resposta clínica de pacientes com pneumonia associada a ventilador.
12 Abr, 2022 | 12:35hComentário: Can Gram Stains Guide Antibiotics for Pneumonia in Critical Care? – Medscape (necessário cadastro gratuito)
Comentário no Twitter
RCT found gram stain-guided antibiotic therapy for critically ill patients with VAP was noninferior to guideline-based antibiotics, with a reduction in antipseudomonal & antiMRSA use. https://t.co/1yoHO2pnER
— JAMA Network Open (@JAMANetworkOpen) April 8, 2022
Diretriz clínica do Reino Unido para prevenção e tratamento de osteoporose.
12 Abr, 2022 | 12:33hUK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis
Sinopse de diretriz | Tratamento da doença multissintoma crônica.
12 Abr, 2022 | 12:24hEstudo randomizado | Eficácia e segurança do gefapixante, um antagonista donreceptor de P2X3, na tosse crônica refratária e na tosse crônica inexplicada.
12 Abr, 2022 | 12:17hEfficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials – The Lancet (link para o resumo – $ para o texto completo)
Comentário no Twitter
For refractory chronic cough or unexplained chronic cough, gefapixant 45 mg twice per day is the first treatment to show efficacy with an acceptable safety profile in phase 3 clinical trials.
New study by Lorcan P McGarvey & colleagues: https://t.co/XnWM75s6lN pic.twitter.com/VyYyRgWTod
— The Lancet (@TheLancet) March 7, 2022
Estudo ASCEND | Efeitos da aspirina sobre a demência e a função cognitiva em pacientes diabéticos.
12 Abr, 2022 | 12:09hEstudo original: Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
Comentário no Twitter (imagens sob licença de https://creativecommons.org/licenses/by/4.0/)
Does aspirin have an effect on dementia and cognitive function? Discover it in the EHJ!https://t.co/u5X1fxrULk#aspirin #dementia #CVD #ASCEND #trial #diabetes #cardiotwitter @escardio @ESC_Journals pic.twitter.com/TyrnUnf0MN
— EHJ Editor-in-Chief (@ehj_ed) April 8, 2022
Estudo de coorte | Uso de inibidores da fosfodiesterase 2 está associado a risco aumentado de eventos adversos oculares.
11 Abr, 2022 | 13:05hRisk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US – JAMA Ophthalmology (gratuito por tempo limitado)
Comunicado de imprensa: U.S. insurance claims show strong link between ED medications and vision problems – University of British Columbia
Comentários:
Phase 4 Studies on Phosphodiesterase 5 Inhibitors – JAMA Ophthalmology (gratuito por tempo limitado)
M-A | Padrões de trombose e desfecho clínico da trombocitopenia trombótica imune induzida por vacina contra COVID-19.
11 Abr, 2022 | 12:58hConteúdos relacionados:
Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.
Review: Vaccine-induced immune thrombotic thrombocytopenia.
Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (vários artigos e fontes sobre o tema)
M-A | Desempenho diagnóstico do CO-RADS para Covid-19.
11 Abr, 2022 | 12:53hConteúdos relacionados: CO-RADS – A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation – Radiology