Alergia e Imunologia
Anticorpos contra COVID-19 persistem por, pelo menos, 9 meses após a infecção – “98,8% das pessoas infectadas em fevereiro/março mostraram nível detectáveis de anticorpos em novembro.”
22 Jul, 2021 | 13:07hComunicado de imprensa: COVID-19 antibodies persist at least nine months after infection – Imperial College London
Estudo original: SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’ – Nature Communications
Diretriz sobre o tratamento das alergias alimentares mediadas por IgE.
22 Jul, 2021 | 12:51hUpdate of the S2k guideline on the management of IgE-mediated food allergies – Allergologie Select
Especialistas recomendam doses de vacina contra a Covid para algumas pessoas menores de 18 anos no Reino Unido – “A sugestão é que a vacina da Pfizer seja oferecida a jovens entre 16 e 18 anos que façam parte de grupos prioritários ou que vivam com pessoas cujo sistema imunológico esteja debilitado.”
20 Jul, 2021 | 10:52hComentários: Experts recommend Covid jabs for some under-18s in UK – BBC
Posicionamento científico | Recomendações para o uso da budesonida inalatória na COVID-19.
19 Jul, 2021 | 10:05hRecommendations for use of topical inhalant budesonide in COVID-19 – HNO
Relacionado: RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19 E Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
Estudos elucidam aspectos da “long COVID”.
19 Jul, 2021 | 10:01hStudies elucidate poorly understood long COVID – CIDRAP
Sintomas de longo prazo após infecção por SARS-CoV-2 em crianças e adolescentes – “Este estudo mostra uma baixa prevalência de sintomas compatíveis com ‘long COVID’ em uma coorte de crianças aleatoriamente selecionadas e avaliadas 6 meses após o teste por sorologia.”
16 Jul, 2021 | 09:59hLong-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – JAMA
Vacinação heteróloga com doses da Oxford–AstraZeneca e da Moderna induz aumento nos níveis de anticorpos neutralizantes em comparação a 2 doses da vacina da Oxford–AstraZeneca.
16 Jul, 2021 | 09:58hHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Relacionado: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. E Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. E RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Comentário no Twitter
Health care workers who had received a dose of ChAdOx1 nCoV-19 were offered either ChAdOx1 nCoV-19 or mRNA-1273 9 to 12 weeks later. Levels of S-specific and RBD-specific IgG increased by a factor of 5 after ChAdOx1 nCoV-19 and by a factor of 115 to 125 after mRNA-1273.
— NEJM (@NEJM) July 14, 2021
Vacinação heteróloga com doses da Oxford–AstraZeneca e da BioNTech/Pfizer induz aumento nos níveis de anticorpos neutralizantes em comparação a 2 doses da vacina da Oxford–AstraZeneca.
16 Jul, 2021 | 09:57hHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Relacionado: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. E Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. E RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Comentário no Twitter
Mix and match vaccines?
2 doses AZ vs AZ and then Pfizer:
"BNT162b2 induced significantly higher frequencies of spike-specific CD4+ and CD8+ T cells and, in particular, high titers of neutralizing antibodies against the B.1.1.7, B.1.351 and P.1 variants" https://t.co/53J2erWVMy pic.twitter.com/aEmqMlhEar— Eric Topol (@EricTopol) July 14, 2021
Estudo randomizado | Banlanivimabe com etesevimabe reduz a mortalidade e a hospitalização em pacientes ambulatoriais com início de Covid-19 (até 3 dias de um teste positivo) que estão sob risco de piora clínica (p.ex., idosos, obesos, diabéticos, imunocomprometidos, portadores de doença cardiovascular).
15 Jul, 2021 | 10:41hBamlanivimab plus Etesevimab in Mild or Moderate Covid-19 – New England Journal of Medicine
Estudo sugere que milhões de crianças pelo mundo interromperam as rotinas de vacinação durante a pandemia.
15 Jul, 2021 | 10:40hMillions of children worldwide missed routine vaccinations during the pandemic, study suggests – CNN
Estudo original: Estimating global and regional disruptions to routine childhood vaccine coverage during the COVID-19 pandemic in 2020: a modelling study – The Lancet
Comentário convidado: Disruptions to childhood immunisation due to the COVID-19 pandemic – The Lancet