Alergia e Imunologia
Vacinação heteróloga com doses da Oxford–AstraZeneca e da BioNTech/Pfizer induz aumento nos níveis de anticorpos neutralizantes em comparação a 2 doses da vacina da Oxford–AstraZeneca.
16 Jul, 2021 | 09:57hHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Relacionado: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. E Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. E RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Comentário no Twitter
Mix and match vaccines?
2 doses AZ vs AZ and then Pfizer:
"BNT162b2 induced significantly higher frequencies of spike-specific CD4+ and CD8+ T cells and, in particular, high titers of neutralizing antibodies against the B.1.1.7, B.1.351 and P.1 variants" https://t.co/53J2erWVMy pic.twitter.com/aEmqMlhEar— Eric Topol (@EricTopol) July 14, 2021
Estudo randomizado | Banlanivimabe com etesevimabe reduz a mortalidade e a hospitalização em pacientes ambulatoriais com início de Covid-19 (até 3 dias de um teste positivo) que estão sob risco de piora clínica (p.ex., idosos, obesos, diabéticos, imunocomprometidos, portadores de doença cardiovascular).
15 Jul, 2021 | 10:41hBamlanivimab plus Etesevimab in Mild or Moderate Covid-19 – New England Journal of Medicine
Estudo sugere que milhões de crianças pelo mundo interromperam as rotinas de vacinação durante a pandemia.
15 Jul, 2021 | 10:40hMillions of children worldwide missed routine vaccinations during the pandemic, study suggests – CNN
Estudo original: Estimating global and regional disruptions to routine childhood vaccine coverage during the COVID-19 pandemic in 2020: a modelling study – The Lancet
Comentário convidado: Disruptions to childhood immunisation due to the COVID-19 pandemic – The Lancet
“Long COVID” e crianças: cientistas correm para encontrar respostas – “Crianças também apresentam ‘long COVID’, mas os pesquisadores ainda estão trabalhando para determinar qual a frequência e a gravidade.”
15 Jul, 2021 | 10:38hLong COVID and kids: scientists race to find answers – Nature
Estudo de coorte | Vacina da Pfizer/BioNTech contra COVID está associada com 78% menos risco de ocorrência de Covid-19 durante a gestação.
14 Jul, 2021 | 11:45hBetween BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women – JAMA
Comentário: Pfizer COVID vaccine shows 78% efficacy in pregnancy – CIDRAP
Muitas crianças da Nova Zelândia estão adoecendo em virtude da “falta de imunidade” gerada pelas medidas de restrição contra a pandemia de Covid.
14 Jul, 2021 | 11:42hNew Zealand children falling ill in high numbers due to Covid ‘immunity debt’ – The Guardian
Relacionado: New Zealand, where Covid-19 is dormant, fights another respiratory virus – The New York Times
“Long Covid”: 39% dos pacientes tratados em ambulatório relatam sintomas persistentes mais de 7 meses depois do diagnóstico de COVID-19.
13 Jul, 2021 | 11:28hComentários: Long COVID symptoms in a third of people with COVID-19 – American College of Physicians E Covid-19: 1-in-3 Patients Reported Long-Hauler Symptoms – Physician’s Weekly
Comentário no Twitter
A new prospective cohort study of >400 people with mild to moderate (outpatient) covid at 7-9 months: nearly 1 of 3 had persistent symptoms #LongCovid @AnnalsofIM
https://t.co/ix1Hhsm0iZ
by @mayssamnehme and colleagues pic.twitter.com/Uc4UEclDvA— Eric Topol (@EricTopol) July 5, 2021
[Preprint] “Long Covid”: sintomas persistentes após infecção por SARS-CoV-2 em uma amostra aleatória de 508.707 pessoas da comunidade.
13 Jul, 2021 | 11:27hComentário: Study explores the prevalence of long COVID in England – News Medical
OMS alerta quanto à mistura e à combinação de vacinas contra a COVID.
13 Jul, 2021 | 11:26hWHO warns against mixing and matching COVID vaccines – Reuters
Comentário: WHO cautions data still limited on mixing COVID-19 vaccines, but Canadian officials say it’s OK – CTV News
Relacionado: Germany issues world’s strongest recommendation for mixing Covid-19 vaccines. E [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. E Perspective | Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems. E RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects. E Should you mix and match COVID-19 vaccines? Scientists are seeking answers
Comentário no Twitter
The World Health Organization's chief scientist on Monday advised against people mixing and matching COVID-19 vaccines from different manufacturers, calling it a "dangerous trend" since there was little data available about the health impact. https://t.co/Oog6fWDSMz
— Reuters Health (@Reuters_Health) July 13, 2021
Casos extremamente raros de Guillain-Barré relatados com a vacina da Johnson & Johnson contra a Covid-19.
13 Jul, 2021 | 11:24hJ&J’s Covid-19 vaccine may trigger neurological condition in rare cases, FDA says – STAT
Ver também: Johnson & Johnson Vaccine Is Linked To Neurological Disorder In Extremely Rare Cases – NPR E F.D.A. Attaches Warning of Rare Nerve Syndrome to Johnson & Johnson Vaccine – The New York Times