Arquivos do dia: Dezembro 8, 2021

OMS faz recomendação contra o uso de plasma convalescente para tratar COVID-19.

8 Dez, 2021 | 13:22h

Comunicado de imprensa: WHO recommends against the use of convalescent plasma to treat COVID-19 – World Health Organization

Ver orientação: WHO’s living guidelines on COVID-19 therapeutics

Infográfico: A living WHO guideline on drugs for covid-19 – The BMJ

 

Comentário no Twitter (fio – clique para saber mais)

Convalescent plasma is a transfusion of blood plasma from someone who has recovered from #COVID19, and is used as a treatment for COVID19 https://t.co/Bobq7OTDGq pic.twitter.com/pfO1sFvUpJ

— World Health Organization (WHO) (@WHO) December 7, 2021

 

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Um primeiro e pequeno estudo sugere que a variante Ômicron é uma ameaça maior à imunidade contra Covid-19 do que outras variantes.

8 Dez, 2021 | 13:20h

A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants – STAT

Estudo original: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection – medRxiv

 

Comentário do autor no Twitter (fio – clique para saber mais)

We have completed our first experiments on neutralization of Omicron by Pfizer BNT162b2 vaccination elicited immunity

Manuscript available at https://t.co/rGaEB9GdmS

and should be available on medRxiv in the coming days

— Alex Sigal (@sigallab) December 7, 2021

Ver também (fio – clique para saber mais)

New work from AHRI's @sigallab strongly suggests that the SARS-CoV-2 #Omicron variant escapes antibody immunity induced by the Pfizer vaccine, but that considerable immunity is retained in people who were both vaccinated & previously infected. https://t.co/AZWi3qexin pic.twitter.com/3phPFyKEPh

— Africa Health Research Institute (@AHRI_News) December 7, 2021

 

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[Preprint] Risco de internação, doença grave e mortalidade por COVID-19 em crianças infectadas pelo SARS-CoV-2 na Alemanha – “A taxa de internação geral associada com infecção por SARS-CoV-2 foi de 35,9 por 10.000 crianças; a taxa de admissão em UTI foi de 1,7 por 10.000 e a taxa de casos fatais foi de 0,09 por 10.000.”

8 Dez, 2021 | 13:18h

Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany – medRxiv

Conteúdos relacionados:

Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.

Review: Should children under 12 years of age be vaccinated against COVID-19?

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

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Estudo randomizado | Em pacientes com Covid-19 grave, o cateter nasal de alto fluxo reduziu a chance de ventilação mecânica invasiva e diminuiu o tempo de recuperação clínica, em comparação à oxigenoterapia convencional.

8 Dez, 2021 | 13:16h

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial – JAMA

Conteúdos relacionados:

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.

[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

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Estudo randomizado de fase 2 | Imunogenicidade e segurança da terceira dose da CoronaVac e persistência imune de esquema de 2 doses.

8 Dez, 2021 | 13:15h

Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials – The Lancet Infectious Diseases

Comentário convidado: Booster doses for inactivated COVID-19 vaccines: if, when, and for whom – The Lancet Infectious Diseases

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Vídeo | Atualização sobre COVID-19: a variante Ômicron.

8 Dez, 2021 | 13:13h

COVID-19 Update: Omicron Variant – JAMA

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Editorial | A variante Ômicron é ruim, mas a resposta global é pior – “A pandemia não vai acabar enquanto a equidade de vacinas continuar sendo empurrada para as margens.”

8 Dez, 2021 | 13:12h

Omicron is bad but the global response is worse – Nature

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Além da Ômicron: o que está por vir quanto à evolução viral da COVID.

8 Dez, 2021 | 13:11h

Beyond Omicron: what’s next for COVID’s viral evolution – Nature

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Posicionamento ESC | Seguimento ótimo após embolia pulmonar aguda.

8 Dez, 2021 | 13:09h

Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society – European Heart Journal

 

Comentário no Twitter

Do you routinely discuss how/when to resume sporting activities and traveling with your PE patients? Or future cardiovascular risk? Check this recent ESC/ERS position paper on optimal follow-up of acute PE for these and other key aspects of counselling: https://t.co/KEQ7FnFwXX

— Erik Klok (@Erik_Klok_MD) December 7, 2021

 

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Aconselhamento Prático da AAN | Suspensão de anticonvulsivos em pacientes evoluindo sem crises epiléticas.

8 Dez, 2021 | 13:08h

Antiseizure Medication Withdrawal in Seizure-Free Patients: Practice Advisory Update Summary: Report of the AAN Guideline Subcommittee – Neurology

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