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Arquivos do dia: Outubro 4, 2021

[Comunicado de imprensa – ainda não publicado] Merck anuncia que o antiviral oral Molnupiravir reduziu o risco de internação ou morte em cerca de 50%, comparado ao placebo, em pacientes com COVID-19 leve ou moderada.

4 Out, 2021 | 10:38h

Merck and Ridgeback’s Investigational Oral Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate COVID-19 in Positive Interim Analysis of Phase 3 Study

Comentários:

Expert reaction to interim analysis of oral antiviral molnupiravir – Science Media Centre

Merck’s antiviral pill reduces hospitalization of Covid patients, a possible game-changer for treatment – STAT

Covid antiviral pill can halve risk of hospitalization – BBC

Why Merck’s Covid-19 pill molnupiravir could be so important – Vox

‘Unquestionably a game changer!’ Antiviral pill cuts COVID-19 hospitalization risk – Researchers excited about Merck drug, but caution data are preliminary and price is high – Science

 

Comentários no Twitter

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Trombose e trombocitopenia imune induzidas por vacina: resumo da diretriz NICE.

4 Out, 2021 | 10:36h

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance – The BMJ

Diretriz original: NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Conteúdos relacionados:

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (vários artigos e fontes sobre o tema)

A pandemia arrefecerá até se tornar uma doença comum, como a gripe? O mundo está observando a Dinamarca para ter pistas.

4 Out, 2021 | 10:34h

Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues – Science

[Preprint] Avaliação do impacto da COVID-19 nos países em desenvolvimento: revisão sistemática, metanálise e implicações de políticas públicas.

4 Out, 2021 | 10:33h

Assessing the Burden of COVID-19 in Developing Countries: Systematic Review, Meta-Analysis, and Public Policy Implications – medRxiv

 

Comentário no Twitter

 

Editorial | Ética clínica: consentimento para vacinação de crianças.

4 Out, 2021 | 10:32h

Clinical ethics: consent for vaccination in children – Archives of Disease in Childhood

Nova análise mostra que os benefícios de se aplicar 2 doses de vacina contra COVID-19 em crianças de 12 a 17 anos supera os riscos.

4 Out, 2021 | 10:30h

Comunicado de imprensa: New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks – The Royal Society of Medicine

Relatório original: Vaccinating adolescents against SARS-CoV-2 in England: a risk-benefit analysis

Contéudo relacionado: Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.

Editorial | Vacinação contra Covid-19: evidência de queda na imunidade é exagerada.

4 Out, 2021 | 10:29h

Covid-19 vaccination: evidence of waning immunity is overstated – The BMJ

Conteúdos relacionados:

COVID vaccine immunity is waning — how much does that matter? – “As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving”.

COVID vaccine effects wane over time but still prevent death and severe illness.

Perspective | What we actually know about waning immunity.

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

Triagem de terapia intensiva sob uma excepcional escassez de recursos.

4 Out, 2021 | 10:26h

Intensive care triage under exceptional resource scarcity – Swiss Medical Weekly

OMS prioriza o acesso a tratamentos de diabetes e câncer na nova Lista de Medicamentos Essenciais.

4 Out, 2021 | 10:25h

Comunicado de imprensa: WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists – World Health Organization

Relatório: WHO model list of essential medicines – 22nd list, 2021 – World Health Organization

Comentário: For the first time, WHO committee recommends action on high-priced essential medicines – STAT

 

Comentário no Twitter (fio – clique para saber mais)

 

Campanha de sobrevivência à sepse: diretrizes internacionais para o tratamento da sepse e do choque séptico 2021.

4 Out, 2021 | 10:23h

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 – Intensive Care Medicine

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