Arquivos do dia: Agosto 6, 2021

[Preprint] Estudo randomizado | Estratégias respiratórias não invasivas na insuficiência respiratória aguda em pacientes com COVID-19 – CPAP reduziu o desfecho composto de entubação ou morte em 30 dias; o uso do cateter nasal de alto fluxo não foi associado a desfechos melhores.

6 Ago, 2021 | 11:58h

An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 – medRxiv

Comentário: Covid: Pressured oxygen reduces ventilator need – BBC

 

Comentário no Twitter (fio – clique para saber mais)

RECOVERY-RS results out, and confirm what most of us have been doing:

CPAP reduces intubation/mortality by 28% compared with no CPAP/HFNO (composite outcome, mostly intubation)
Nasal high flow not so successful

1/https://t.co/bcB2sTdAsu pic.twitter.com/fvT8IbyxUr

— 𝚃𝚘𝚖 𝙻𝚊𝚠𝚝𝚘𝚗 💙 (@LawtonTri) August 5, 2021

 

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Revisão sistemática | “Rendesivir provavelmente tem pouco ou nenhum efeito sobre a mortalidade por todas as causas em até 28 dias em adultos hospitalizados com infecção por SARS-CoV-2. Não estamos certos a respeito dos efeitos deste medicamento sobre a melhora ou a piora clínica.”

6 Ago, 2021 | 11:55h

Remdesivir for the treatment of COVID‐19 – Cochrane Library

Resumo: Remdesivir for the treatment of COVID-19 – Cochrane Library

 

Comentário no Twitter (fio – clique para saber mais)

JUST PUBLISHED – Is #remdesivir an effective treatment for #COVID19? https://t.co/ntgfDQjMqs This @CochraneHaem systematic review looked at this antiviral medicine to see if it's an effective treatment for people in hospital w #COVID & if it causes unwanted effects. 1/5 pic.twitter.com/UtIW83uTtn

— The Cochrane Library (@CochraneLibrary) August 5, 2021

 

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Tratamento com dexametasona e tocilizumabe reduz consideravelmente os níveis de proteína C reativa e procalcitonina, dificultando a detecção de infecções bacterianas secundárias em pacientes com COVID-19.

6 Ago, 2021 | 11:52h

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients – Critical Care

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Imagem clínica | Mucormicose após COVID-19 em paciente com diabetes.

6 Ago, 2021 | 11:51h

Mucormycosis after COVID-19 in a patient with diabetes – The Lancet

Conteúdos relacionados:

COVID-19 and mucormycosis superinfection: the perfect storm.

ECMM/ISHAM recommendations for clinical management of COVID -19 associated mucormycosis in low- and middle-income countries.

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.

Opinion | “Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing” – improper use of antibiotics and higher than usual doses of corticosteroids may be contributing to the emergence of mucormycosis and other fungal co-infections.

What is mucormycosis, the fungal infection affecting COVID patients in India?

[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.

Mucormycosis: The ‘black fungus’ maiming Covid patients in India

Global Guideline for the Diagnosis and Management of Mucormycosis

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Estudo falho sobre ivermectina destaca os desafios dos estudos sobre medicamentos para COVID.

6 Ago, 2021 | 11:49h

Flawed ivermectin preprint highlights challenges of COVID drug studies – Nature

Conteúdos relacionados:

Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

Why was a major study on ivermectin for covid-19 just retracted?

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Revisão sobre COVID-19: manifestações abdominais em adultos e síndrome inflamatória multissistêmica em crianças.

6 Ago, 2021 | 11:47h

Review of COVID-19, part 1: Abdominal manifestations in adults and multisystem inflammatory syndrome in children – Clinical Imaging

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M-A | Achados de radiografia torácica na COVID-19.

6 Ago, 2021 | 11:45h

Systematic review and meta-analysis of chest radiograph (CXR) findings in COVID-19 – Clinical Imaging

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Anormalidades pulmonares intersticiais fibróticas no seguimento de 1 ano com tomografia computadorizada (TC) após COVID-19 grave.

6 Ago, 2021 | 11:43h

Fibrotic Interstitial Lung Abnormalities at 1-year Follow-up CT after Severe COVID-19 – Radiology

Conteúdo relacionado: Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up.

 

Comentário no Twitter

Data on 1 year outcomes for patients with post-COVID lung fibrosis. Small study, very little clinical information, including on treatment, and I object to the use of the term ILA, but overall not suggestive of progressive fibrotic lung disease. Thoughts?https://t.co/Kdt1pmTREl pic.twitter.com/mu1Jd2G6sd

— Anna Podolanczuk (@AnnaPodolanczuk) August 4, 2021

 

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Diretriz prática ESPEN | Nutrição clínica em cirurgia – “Jejum pré-operatório a partir da meia-noite é desnecessário na maioria dos pacientes. Pacientes que serão submetidos a cirurgia e não apresentam risco específico de aspiração podem ingerir líquidos claros até 2 horas antes da anestesia. Alimentos sólidos podem ser ingeridos até 6 horas antes da anestesia.”

6 Ago, 2021 | 11:42h

ESPEN practical guideline: Clinical nutrition in surgery – Clinical Nutrition

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Diretriz PIDS-IDSA sobre diagnóstico e tratamento da osteomielite hematogênica aguda em pediatria.

6 Ago, 2021 | 11:40h

Clinical Practice Guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 Guideline on Diagnosis and Management of Acute Hematogenous Osteomyelitis in Pediatrics – Journal of the Pediatric Infectious Diseases Society

Comunicado de imprensa: New PIDS-IDSA guideline on bone infections in children addresses key diagnostic and treatment questions – Pediatric Infectious Diseases Society

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