Terapia Intensiva

M-A | Associação da administração de ácido tranexâmico com mortalidade e eventos tromboembólicos em pacientes com lesão traumática.

3 Mar, 2022 | 15:24h

Association of Tranexamic Acid Administration With Mortality and Thromboembolic Events in Patients With Traumatic Injury: A Systematic Review and Meta-analysis – JAMA Network Open

Conteúdos relacionados:

M-A: Prehospital Tranexamic Acid reduces mortality among bleeding trauma patients without increasing the risk of venous thromboembolism.

Tranexamic acid after traumatic brain injury: Exploratory analysis combining data from CRASH-2 and CRASH-3 trials suggests reduced mortality

Meta-analysis: Efficacy and safety of tranexamic acid in acute traumatic brain injury

Randomized trial: Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury

Randomized trial: Out-of-hospital tranexamic acid does not improve neurologic outcomes in patients with traumatic brain injury

Editorial: Is Tranexamic Acid Going to CRASH the Management of Traumatic Brain Injury?

Practice-Changing: Tranexamic Acid Reduces the Risk of Head Injury-related Death in Patients with Mild-to-moderate Head Injury

---

Estudo randomizado por cluster | Em adultos com parada cardíaca fora do hospital, a colocação de um dispositivo para via aérea supraglótico resultou em taxas similares de retorno da circulação espontânea em comparação à entubação orotraqueal.

2 Mar, 2022 | 11:45h

Effect of Placement of a Supraglottic Airway Device vs Endotracheal Intubation on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest in Taipei, Taiwan: A Cluster Randomized Clinical Trial – JAMA Network Open

Comentário: Cardiac Arrest Patients Don’t Necessarily Do Better With Intubation— Debate on prehospital advanced airway management continues – MedPage Today (necessário cadastro gratuito)

 

Comentário no Twitter

RCT of out-of-hospital cardiac arrest patients randomized to intubation or supraglottic airways, finds no difference in the rate of sustained return of spontaneous circulation, survival to hospital discharge or favorable neurologic outcomes. https://t.co/GX80iczmHC

— JAMA Network Open (@JAMANetworkOpen) February 18, 2022

 

---

Revisão JACC | Anticoagulação em pacientes com COVID-19.

2 Mar, 2022 | 11:42h

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week – Journal of the American College of Cardiology

Comentário: Review of Anticoagulation in Patients With COVID-19: Key Points – American College of Cardiology

---

Diretriz atualizada da Joint British Diabetes Society for Inpatient Care | Tratamento da cetoacidose diabética em adultos.

1 Mar, 2022 | 15:41h

The management of diabetic ketoacidosis in adults—An updated guideline from the Joint British Diabetes Society for Inpatient Care

---

Estudo randomizado | Melatonina profilática não reduz a incidência de delirium em pacientes em UTI.

1 Mar, 2022 | 15:27h

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial – Intensive Care Medicine (link para o resumo – $ para o texto completo)

 

Comentários no Twitter

Enteral prophylactic melatonin initiated early (within 48h of admission) & continued throughout #ICU (MAX 14 consecutive days) do not ⬇️#delirium prevalence vs placebo, Pro-MEDIC multicentre RCT
➡️12🇦🇺ICUs
➡️841 pts
➡️delirium-free assessments 79.2% vs 80%https://t.co/Gt5o1VuRo7 pic.twitter.com/gPRWxxmhHS

— Intensive Care Medicine (@yourICM) February 28, 2022

In 841 ICU patients with expected stay >72h, 4 mg melatonin within 48h after admission for 14 days vs placebo made no sign. differences in delirium-free assessments, LoS, 90d mortality, nor quality & quantity of sleep
Good bye Melatonin, we had a good timehttps://t.co/d0dayil99W

— Peter Nydahl (@NydahlPeter) February 28, 2022

 

---

Diretriz | Plasmaférese e dosagem de glicocorticoides para pacientes com vasculite associada a ANCA.

28 Fev, 2022 | 13:35h

Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis: a clinical practice guideline – The BMJ

Ver também: The effects of plasma exchange in patients with ANCA-associated vasculitis: an updated systematic review and meta-analysis – The BMJ

 

Comentário no Twitter

New rapid recommendation makes a weak recommendation against plasma exchange in patients with low risk of end stage kidney disease, and a weak recommendation in favour of plasma exchange in patients with moderate-high risk of ESKD https://t.co/PeEjSuRIxI #BMJInfographic pic.twitter.com/YR55t6XYhS

— The BMJ (@bmj_latest) February 25, 2022

 

---

Grandes queimados – Parte 1 | Epidemiologia, fisiopatologia e tratamento inicial.

25 Fev, 2022 | 14:12h

Major burns: Part 1. Epidemiology, pathophysiology and initial management – BJA Education

---

Revisão | Extubação traqueal segura após anestesia geral.

25 Fev, 2022 | 14:11h

Safe tracheal extubation after general anaesthesia – BJA Education

---

Revisão | O anestesista e procedimentos geradores de aerossol.

25 Fev, 2022 | 14:10h

Aerosol-generating procedures and the anaesthetist – BJA Education

---

Estudo randomizado | Em sobreviventes comatosos de parada cardíaca, uma estratégia de supressão da atividade eletroencefalográfica (EEG) rítmica e periódica com uso de medicação anticonvulsivante não melhorou os desfechos neurológicos.

24 Fev, 2022 | 15:54h

Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

In trial of comatose patients after cardiac arrest, intensive antiseizure treatment adapted from protocols for status epilepticus did not result in fewer poor outcomes at 3 mos than standard treatment. https://t.co/dpH5cgwhvW pic.twitter.com/zVBHBYMRK9

— NEJM (@NEJM) February 23, 2022

 

---