Reumatologia

Estudo randomizado | Suplementação de vitamina D para idosos (média de idade: 67 anos) por 5 anos reduziu o risco de doenças autoimunes em 22%. O risco absoluto no grupo em tratamento foi de 0,95% vs. 1,19% no grupo placebo.

31 Jan, 2022 | 08:51h

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial – The BMJ

Comentário: Vitamin D and fish oil supplements may help prevent autoimmune disease, study says – CNN

Conteúdos relacionados:

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

RCT: Vitamin D supplementation is not beneficial for the prevention of cardiovascular disease and cancer.

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

---

EULAR e ACR pontos a se considerar para diagnóstico e tratamento de patologias autoinflamatórias do interferon: CANDLE/PRAAS, SAVI e AGS.

31 Jan, 2022 | 08:45h

The 2021 EULAR and ACR points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS – Annals of Rheumatic Diseases

---

Resumo de diretriz | Tratamento dos 10 eventos adversos imunológicos mais comuns em pacientes em imunoterapia.

31 Jan, 2022 | 08:39h

Management of the Top 10 Most Common Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy – JCO Oncology Practice

Artigo original: ASCO Guideline Update: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

Conteúdos relacionados:

Clinical practice guideline on immune checkpoint inhibitor-related adverse events.

NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (várias fontes sobre o tema)

---

O lado positivo da moeda: a pandemia de SARS-CoV-2 nos ensinou sobre o quanto a telemedicina é útil como procedimento padrão de cuidado na vida real.

28 Jan, 2022 | 17:14h

The positive side of the coin: Sars-Cov-2 pandemic has taught us how much Telemedicine is useful as standard of care procedure in real life – Clinical Rheumatology

---

Revisão | Artrite idiopática juvenil.

28 Jan, 2022 | 16:50h

Juvenile idiopathic arthritis – Nature Reviews Disease Primers (se o acesso a este link for pago, tente este)

Infográfico: Juvenile idiopathic arthritis (se o acesso a este link for pago, tente este)

 

Comentário no Twitter

Get Primed on juvenile idiopathic #arthritis with our NEW PrimeView! FREE to download this week!https://t.co/MUVlIRWCfY pic.twitter.com/G5woxpOlKI

— Nature Reviews Disease Primers (@DiseasePrimers) January 27, 2022

 

---

Revisão narrativa e abordagem prática | Efeitos colaterais de curto prazo relacionados a glicocorticoides e reações adversas.

28 Jan, 2022 | 15:56h

Short-term glucocorticoid-related side effects and adverse reactions: a narrative review and practical approach – Swiss Medical Weekly

---

Estudo de coorte | Entre pacientes com hepatite B resolvida e doenças autoimunes concomitantes, a exposição a doses de prednisona maiores que 20 mg/dia foi associada com alto risco para reativação do vírus da hepatite B (VHB) ou surto de hepatite.

21 Jan, 2022 | 15:39h

Average corticosteroid dose and risk for HBV reactivation and hepatitis flare in patients with resolved hepatitis B infection – Annals of Rheumatic Disease (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

Patients with time-weighted average prednisone dose greater than 20 mg/day would be classified as the high risk for HBV reactivation or hepatitis flare. Prophylactic Anti-HBV therapy may be needed for these high-risk patientshttps://t.co/qLuirdyXDK pic.twitter.com/yDJ4c072qm

— ARD & RMD Open (@ARD_BMJ) December 23, 2021

 

---

Diretriz de consenso para avaliação e tratamento de espondiloartrite axial não radiográfica.

21 Jan, 2022 | 15:27h

Australian Consensus Statements for the Assessment and Management of Non-radiographic Axial Spondyloarthritis – Rheumatology and Therapy

---

Revisão sistemática | Comparação de manifestações clínicas na artrite reumatoide vs. espondiloartrite.

21 Jan, 2022 | 15:26h

Comparison of Clinical Manifestations in Rheumatoid Arthritis vs. Spondyloarthritis: A Systematic Literature Review – Rheumatology and Therapy

---

Recomendações de consenso sobre o tratamento de comorbidades selecionadas incluindo doença cardiovascular, osteoporose e doença pulmonar intersticial na artrite reumatoide.

20 Jan, 2022 | 22:48h

Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis – Medicine

---