Acesso livre
Acesso livre

Pneumologia

Evidências reforçam que infecções por SARS-CoV-2 em indivíduos já vacinados (“breakthrough infections”) podem facilmente disseminar a variante Delta.

23 Ago, 2021 | 13:21h

Evidence mounts that people with breakthrough infections can spread Delta easily – National Geographic

Estudo original: Shedding of Infectious SARS-CoV-2 Despite Vaccination when the Delta Variant is Prevalent – Wisconsin, July 2021 – medRxiv

 

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Entre pacientes que recebem vacina de mRNA, sintomas clinicamente significativos são mais frequentes após a 2ª dose, após a 1ª dose em pacientes com infecção prévia por SARS-CoV-2 e naqueles que receberam a vacina da Moderna.

23 Ago, 2021 | 13:19h

Association of Vaccine Type and Prior SARS-CoV-2 Infection With Symptoms and Antibody Measurements Following Vaccination Among Health Care Workers – JAMA Internal Medicine

 

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Comentários de estudo | Ventilação não invasiva para pacientes com COVID-19. Estudo Recovery RS.

23 Ago, 2021 | 13:18h

Comentário 1: JC: Non-invasive ventilation for COVID 19 patients. The Recovery RS trial – St Emlyn’s

Comentário 2: An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 – The Bottom Line

Estudo original: [Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

Estudo laboratorial mostra que a estratégia de vacinação heteróloga AstraZeneca + Pfizer propicia uma imunogenicidade mais potente contra Covid comparada a estratégias homólogas AZ + AZ ou Pfizer + Pfizer.

23 Ago, 2021 | 13:16h

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study – The Lancet Respiratory Medicine

Comentário convidado: Heterologous ChAdOx1-nCoV19–BNT162b2 vaccination provides superior immunogenicity against COVID-19

Conteúdos relacionados:

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (vários artigos sobre o tema)

 

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Diretriz NICE | Síndrome da apneia/hipopneia obstrutiva do sono e síndrome da hipoventilação por obesidade em maiores de 16 anos.

23 Ago, 2021 | 13:07h

Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s – National Institute for Health and Care Excellence

Estudo | Uso de macrolídeo está associado a zumbido incidente e prevalente.

23 Ago, 2021 | 12:49h

Macrolide-associated ototoxicity: a cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss – Journal of Antimicrobial Chemotherapy

Comentário: Macrolide Use and Tinnitus: A New Safety Ringtone? – NEJM Journal Watch (gratuito por tempo limitado)

[Preprint] Eficácia da vacina da Pfizer contra a variante Delta diminui mais rapidamente do que a da AstraZeneca; ambas oferecem a mesma proteção depois de 4 meses.

20 Ago, 2021 | 12:35h

Impact of Delta on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK – University of Oxford

Comentários:

Vaccines Are Less Effective Against Delta—And Pfizer’s Protection Wanes Rapidly—But Are The Best Way To Protect Against Covid, Large Study Finds – Forbes

Expert reaction to preprint looking at the impact of the delta variant on vaccine effectiveness – Science Media Centre

Pfizer vaccine effectiveness declines faster than AstraZeneca – study – Evening Standard

 

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Covid-19: quantas variantes existem e o que se sabe sobre elas?

20 Ago, 2021 | 12:32h

Covid-19: How many variants are there, and what do we know about them? – The BMJ

 

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Novas variantes do SARS-Cov-2 mudaram a pandemia. O que o vírus fará a seguir?

20 Ago, 2021 | 12:31h

New SARS-CoV-2 variants have changed the pandemic. What will the virus do next? – Science

 

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Um alerta de Israel: a vacinação atenua, mas não acaba com a variante Delta.

20 Ago, 2021 | 12:29h

A grim warning from Israel: Vaccination blunts, but does not defeat Delta – Science

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