Acesso livre
Acesso livre

Pediatria

Avaliação do trióxido arsênico e do ácido retinoico all-trans para o tratamento da leucemia promielocítica aguda pediátrica.

15 Nov, 2021 | 13:34h

Assessment of Arsenic Trioxide and All-trans Retinoic Acid for the Treatment of Pediatric Acute Promyelocytic Leukemia: A Report From the Children’s Oncology Group AAML1331 Trial – JAMA Oncology

Comunicado de imprensa: Drug combination helps children with acute promyelocytic leukemia avoid conventional chemotherapy – NIH News Releases

 

Comentário no Twitter

 

Mortes de crianças e jovens na Inglaterra após infecção por SARS-CoV-2 durante o 1º ano da pandemia – “Ao todo, 99,995% das crianças e jovens com teste positivo para SARS-CoV-2 sobreviveram.”

12 Nov, 2021 | 13:48h

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – Nature

Conteúdo relacionado:

[Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.

Study: Children and young people remain at low risk of COVID-19 mortality

 

Comentários no Twitter

 

OMS, CDC | Progresso global contra o sarampo fica ameaçado em meio à pandemia de COVID-19.

12 Nov, 2021 | 13:36h

Comunicado de imprensa: Global progress against measles threatened amidst COVID-19 pandemic – World Health Organization

Relatório: Progress Toward Regional Measles Elimination — Worldwide, 2000–2020 – CDC Morbidity and Mortality Weekly Report

Comentário: Measles is a renewed global threat after 22 million babies missed their vaccines during the pandemic, CDC warns – CNN

 

Comentário no Twitter (fio – clique para saber mais)

 

Atualização sobre a síndrome inflamatória multissistêmica em crianças relacionada ao SARS-CoV-2.

11 Nov, 2021 | 16:17h

An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2 – The Pediatric Infectious Diseases Journal

Conteúdos relacionados:

Ten Things to Know About Multisystem Inflammatory Syndrome in Children (MIS-C).

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

Sequenciamento genômico completo pode melhorar o diagnóstico de doenças raras e encurtar a jornada diagnóstica para os pacientes.

11 Nov, 2021 | 16:13h

Comunicado de imprensa: Whole genome sequencing improves diagnosis of rare diseases and shortens diagnostic journeys for patients – Queen Mary University of London

Estudo original: 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report – New England Journal of Medicine

Conteúdos relacionados:

RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.

Review: Genome sequencing as a diagnostic test.

Estudo randomizado | Rastreamento universal no ensino médio pode ajudar a identificar e iniciar o tratamento de depressão em adolescentes.

11 Nov, 2021 | 16:00h

Screening in High Schools to Identify, Evaluate, and Lower Depression Among Adolescents: A Randomized Clinical Trial – JAMA Network Open

Comunicado de imprensa: School-based screening increases identification of, treatment for depression – Penn State

Comentários:

Universal Depression Screening in Schools—Promises and Challenges in Addressing Adolescent Mental Health Need – JAMA Network Open

Universal School-Based Depression Screening May Connect More Students to Care – Psychiatric News Alert

 

Comentários no Twitter

 

Estudo randomizado | Vacina da Pfizer mostra 90,7% de eficácia na prevenção de Covid-19 em crianças de 5 a 11 anos de idade.

10 Nov, 2021 | 12:55h

Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age – New England Journal of Medicine

 

Comentário no Twitter

 

Estudo de coorte | Exposição intraútero a 17-alfa-hidroxiprogesterona está associada a risco aumentado de câncer nos descendentes.

10 Nov, 2021 | 12:38h

In utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring – American Journal of Obstetrics and Gynecology (link para o resumo – $ para o texto completo)

Comentário: Drug used to prevent miscarriage increases risk of cancer in offspring – The University of Texas Health Science Center at Houston

Conteúdo relacionado: Randomized Trial: Injectable 17-α-hydroxyprogesterone Not Effective for the Prevention of Recurrent Preterm Birth

Choosing Wisely | Nove recomendações otolaringológicas pediátricas.

9 Nov, 2021 | 12:06h

Choosing Wisely Canada – pediatric otolaryngology recommendations – Journal of Otolaryngology – Head & Neck Surgery

Ver lista completa de práticas de baixo valor: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia E Choosing Wisely Canada

[Ainda não publicado] Farmacêutica Sinovac afirma que sua vacina contra Covid-19 é segura para crianças e mesmo bebês a partir dos 6 meses de vida.

8 Nov, 2021 | 12:45h

Chinese drug firm Sinovac says Covid-19 vaccine safe for children, babies as young as six months old; submits data to Hong Kong government – South China Morning Post

Conteúdos relacionados:

Randomized phase 1/2 trial: Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in children and adolescents aged 3–17 years.

Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years.

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