Pediatria
Nova terapia gênica para hemofilia A induz uma expressão sustentada de fatores de coagulação e reduziu os eventos hemorrágicos.
19 Nov, 2021 | 12:51hComunicado de imprensa: Novel gene therapy for hemophilia a leads to sustained expression of clotting factor and reduced bleeding events – Children’s Hospital of Philadelphia
Estudo original: Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A – New England Journal of Medicine
Comentário no Twitter
3.5 years after therapy with factor VIII-containing adeno-associated virus, 16 of 18 men with hemophilia A had enough factor VIII expression that bleeding events were reduced to nearly zero and prophylaxis was discontinued. https://t.co/n3cPyjGDkn pic.twitter.com/vPyz0OmT1S
— NEJM (@NEJM) November 18, 2021
Debate Pro-Con | Todos os bebês devem ter seu genoma sequenciado ao nascimento?
19 Nov, 2021 | 12:50hShould all babies have their genome sequenced at birth? – The BMJ
Conteúdos relacionados:
Review: Genome sequencing as a diagnostic test.
Revisão | Crianças com menos de 12 anos deveriam ser vacinadas contra COVID-19?
19 Nov, 2021 | 12:37hShould children be vaccinated against COVID-19? – Archives of Disease in Childhood
Comentário do autor no Twitter (fio – clique para saber mais)
Should #children be vaccinated against #COVID19?
Our review outlines the points to consider in weighing up whether all healthy children under 12y should be vaccinated against COVID-19.https://t.co/JtoOr2TZoq#medpeds #IDTwitter #PaedsID #tweetiatrician #paediatrics
🧵1/n pic.twitter.com/g4UGu3pMsE
— Nigel Curtis (@nigeltwitt) November 6, 2021
Covid: no Reino Unido, crianças só devem tomar a dose da vacina 12 semanas depois de uma infecção.
19 Nov, 2021 | 12:35hCovid: Children told to delay jab for 12 weeks after infection – BBC
Relatório original: Joint Committee on Vaccination and Immunisation (JCVI) advice on COVID-19 vaccination in people aged 16 to 17 years: 15 November 2021
Novos níveis de referência ACR para radiação diagnóstica para os 10 principais exames de TC.
19 Nov, 2021 | 12:14hComunicado de imprensa: New Radiation Diagnostic Reference Levels for Top 10 Pediatric CT Exams – American College of Radiology
Diretriz original: U.S. Diagnostic Reference Levels and Achievable Doses for 10 Pediatric CT Examinations – Radiology
Comentário: ACR releases new benchmarks to help radiology departments optimize radiation dose levels – Health Imaging
Estudo randomizado | Em crianças com hemangioma infantil, nadolol é não inferior ao propranolol e pode ser uma alternativa eficaz e segura em casos de não resposta ao propranolol ou de eventos adversos.
19 Nov, 2021 | 12:12hComentário: Oral Nadolol Feasible for the Treatment of Infantile Hemangiomas – HealthDay
Comentário no Twitter
A randomized clinical trial found #nadolol is non-inferior to in patients with infantile hemangioma—a safe and efficacious alternative when fast response is needed https://t.co/ECVFfFPBJ2
— JAMA Pediatrics (@JAMAPediatrics) November 9, 2021
Seguimento de longo prazo de estudo randomizado mostrou que bebês que receberam fórmula láctea enriquecida com suplementos ou nutrientes não apresentaram desempenho acadêmico melhor na adolescência.
17 Nov, 2021 | 12:43hComunicado de imprensa: Study finds no benefit of enriched formula milks on later academic performance – British Medical Journal
Editorial: Enriched formula milks and academic performance in later childhood – The BMJ
Comentário no Twitter
Children who are given nutrient or supplement enriched formula milk as babies do not appear to have higher exam scores as adolescents than those fed with standard formula, suggests a study published @bmj_latest today https://t.co/QmE2QxRlXm @DrMaxVerfuerden
— BMJ (@bmj_company) November 11, 2021
#AHA21 – Estudo randomizado | Entre crianças e adolescentes submetidos a rastreamento ecocardiográfico e diagnosticados com doença cardíaca reumática latente, antibioticoprofilaxia secundária com penicilina G benzatina por 2 anos foi associada com redução da progressão ecocardiográfica (0,8 vs, 8,2% no grupo controle).
15 Nov, 2021 | 13:53hSecondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentários:
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology
Comentários no Twitter
One of most important studies ever Rheumatic Heart Disease @NEJM https://t.co/U8FuNHLqCJ RCT evidence 2ry prophylaxis reduces progression latent RhD pic.twitter.com/UycTElr7QM
— Michael Marks (@dr_michaelmarks) November 13, 2021
Penicillin slowed the devastating impact of rheumatic heart disease among children in Uganda. Findings of a large-scale, randomized controlled trial were completed in Uganda. Group A strep underlies rheumatic heart disease. New England Journal of Medicine https://t.co/1PKFJ12FvC
— delthia ricks 🔬 (@DelthiaRicks) November 13, 2021
Mortalidade global, regional e nacional entre jovens de 10 a 24 anos, 1950–2019: uma análise sistemática do Global Burden of Disease Study 2019.
15 Nov, 2021 | 13:43hComentários: Nearly two-thirds of those who died young in 2019 were male, research finds – The Guardian
Comentários no Twitter (fio – clique para saber mais)
✨🆕✨#GBDStudy 2019 analysis published by @TheLancet examined the global, regional, and national #mortality among young people aged 10-24 between 1950-2019, finding that mortality increased in 2019 with age globally🌎, particularly in males
Read here ⤵https://t.co/6gprq6gM0Z
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) October 29, 2021
Estudo de coorte sugere que tomografia computadorizada com dose baixa vs. dose padrão de radiação têm acurácia diagnóstica similar na suspeita de apendicite aguda.
15 Nov, 2021 | 13:39hComunicado de imprensa: Doctors can use CT scans with less radiation to diagnose appendicitis – Oxford University
Estudo original: Diagnostic accuracy using low-dose versus standard radiation dose CT in suspected acute appendicitis: prospective cohort study – British Journal of Surgery (link para o resumo – $ para o texto completo)