Gestão de Antimicrobianos

Genotipagem rápida no local de atendimento para evitar a ototoxicidade induzida por aminoglicosídio na UTI neonatal.

23 Mar, 2022 | 11:27h

Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care – JAMA Pediatrics

Editorial: Genetic Testing in Newborns Moves From Rare to Routine Application

 

Comentário no Twitter

The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity
The MT-RNR1 POCT was able to genotype the m.1555A>G variant in 26 minutes. #IDTwitter #medtwitter #TwitteRx #MedEd #PIDTwitter https://t.co/BbkpNMiNHN

— Antibiotic Steward Bassam Ghanem🆔🔥 (@ABsteward) March 21, 2022

 

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Estudo randomizado | Contezolida oral vs. linezolida em adultos com infecções cutâneas e de partes moles complicadas.

21 Mar, 2022 | 15:58h

A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections – Journal of Antimicrobial Therapy (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

Phase III efficacy & safety of oral contezolid Vs linezolid in adults with c.SSTIs
📌Non inferior
📌Interestingly:Contezolid demonstrated significant lower incidence thrombocytopenia (0% Wow vs 2.3%) & leucopenia (0.3% vs 3.4%) than linezolid
📌QIDP https://t.co/wSvxUInnkZ

— Antibiotic Steward Bassam Ghanem (@ABsteward) March 11, 2022

 

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Antibioticoterapias para prevenir exacerbações agudas recorrentes da doença pulmonar obstrutiva crônica (DPOC): além das diretrizes.

17 Mar, 2022 | 12:43h

Antimicrobial therapies for prevention of recurrent acute exacerbations of COPD (AECOPD): beyond the guidelines – Respiratory Research

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4 ações prioritárias para desacelerar a pandemia silenciosa de resistência a antibióticos.

16 Mar, 2022 | 17:36h

Four Priority Actions to Slow the Silent Pandemic of Antimicrobial Resistance – Health Policy Watch

Conteúdos relacionados:

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.

Perspective | The hidden epidemic: Antibiotic resistance is approaching a crisis point, and the world needs to act.

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Como tratar | Infecção por Clostridioides difficile em crianças.

16 Mar, 2022 | 17:24h

How to: Clostridioides difficile infection in children – Clinical Microbiology and Infection

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M-A | Redosagem intraoperatória da antibioticoprofilaxia cirúrgica em adição à profilaxia pré-operatória vs. profilaxia em dose única para a prevenção de infecção de sítio cirúrgico.

16 Mar, 2022 | 17:22h

Intraoperative Redosing of Surgical Antibiotic Prophylaxis in Addition to Preoperative Prophylaxis Versus Single Dose Prophylaxis for the Prevention of Surgical Site Infection: A Meta-Analysis and GRADE Recommendation – Annals of Surgery

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A maioria das prescrições de antibioticoprofliaxia antes de consultas odontológicas é inconsistente com as diretrizes.

16 Mar, 2022 | 17:19h

Antibiotic prophylaxis prescriptions prior to dental visits in the Veterans’ Health Administration (VHA), 2015–2019 – Infection Control & Hospital Epidemiology (link para o resumo – $ para o texto completo)

Comentário: Most antibiotics prescribed for dental visits inconsistent with guidelines, study finds – Healio (link para o resumo – $ para o texto completo)

 

Comentário no Twitter

New in @ICHEJournal from @SUDAmonas et al:

➡️ Five out of six antibiotics prescribed for dental infection prophylaxis in VA were inconsistent with guidelines. Improving prophylaxis appropriateness may have large implications for stewardship.

📄: https://t.co/HTTO9eaYo5 pic.twitter.com/Ay9zgJIqml

— ICHE Journal (@ICHEJournal) February 23, 2022

 

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M-A | Desfechos similares de betalactâmico em monoterapia vs. terapia combinada para infecções de corrente sanguínea ou pneumonia por Pseudomonas aeruginosa.

15 Mar, 2022 | 13:02h

Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link para o resumo – $ para o texto completo)

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Infecções associadas a cuidados de saúde em pacientes adultos de UTI: mudanças em epidemiologia, diagnóstico, prevenção e contribuição das novas tecnologias.

14 Mar, 2022 | 13:44h

Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies – Intensive and Critical Care Nursing

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Estudo randomizado | Efetividade da fosfomicina no tratamento de infecções de trato urinário por Escherichia coli multirresistente.

14 Mar, 2022 | 13:37h

Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial – JAMA Network Open

Comentários:

The Role of Intravenous Fosfomycin: Finding Our Way Out of Dante’s Forest Dark – JAMA Network Open

Fosfomycin Not Noninferior to Comparators for Bacteremic UTI – HealthDay

‘Forgotten’ antibiotic recovered for resistant bacterial infections – University of Seville

 

Comentário no Twitter

In this RCT, fosfomycin did not demonstrate noninferiority in MDR-E coli bacteremic UTI, mostly due to adverse event-related withdrawals in mITT, but showed efficacy in per protocol analysis. #FORESTtrial @jesusrbano https://t.co/oiPtiQo2XA pic.twitter.com/Q44QQb18cN

— JAMA Network Open (@JAMANetworkOpen) January 13, 2022

 

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