Gestão de Antimicrobianos
Prevalência de rotulagem da alergia à penicilina variou de 0,9% a 10,2% entre práticas em uma ampla coorte pediátrica, levantando questões sobre a validade desses rótulos e o uso desnecessário de antibióticos de segunda linha que pode se seguir.
29 Mar, 2022 | 14:12hM-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy
Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
Comentário no Twitter
In this cohort study of more than 330,000 children, less than 5% were labeled with penicillin allergy with wide variation across practices, with 8% of those labeled despite not receiving any penicillin prescription. https://t.co/kvXcm1RKRd
— JAMA Network Open (@JAMANetworkOpen) March 15, 2022
M-A | Mortalidade da bacteriemia por Staphylococcus aureus.
25 Mar, 2022 | 15:31hM-A | Rastreamento da tuberculose entre pacientes HIV-positivos internados.
25 Mar, 2022 | 15:30h
Comentário no Twitter
Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis https://t.co/DqTUr2JxHy In setting where TB prevalence is > 10%, WHO now strongly recommends molecular rapid diagnostic testing in all medical inpatient PWH.
— Carlos del Rio (@CarlosdelRio7) March 24, 2022
Estudo randomizado | Tratamento com dose única de anfotericina B lipossomal para meningite por criptococo.
25 Mar, 2022 | 15:01hSingle-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link para o resumo – $ para o texto completo)
Comentário no Twitter
Cryptococcal meningitis is a major complication of HIV infection. Single-dose liposomal amphotericin B combined with flucytosine and fluconazole was noninferior to the WHO-recommended treatment and was associated with fewer adverse events. https://t.co/cg9DqSDhyN pic.twitter.com/SrKx4tDaph
— NEJM (@NEJM) March 23, 2022
OMS lança diretrizes de tratamento clínico para influenza.
24 Mar, 2022 | 12:36hComunicado de imprensa: WHO releases clinical management guidelines for influenza – World Health Organization
Relatório original: Guidelines for the clinical management of severe illness from influenza virus infections – World Health Organization
Incidência de complicações oculares em pacientes com candidíase disseminada e implicações para a prática de exames oculares de rotina.
24 Mar, 2022 | 11:58hPrevenção e tratamento do resfriado comum: quais são as evidências?
23 Mar, 2022 | 11:58hPreventing and treating the common cold: what’s the evidence? – Evidently Cochrane
Comentário no Twitter
Preventing & treating the #CommonCold: what’s the evidence? https://t.co/kWHTwX1spb
Dr Lynda Ware looks at 14 possible interventions, including:
☀️ vitamin supplements,
💊 medicines,
🍯 home & herbal remedies
💉 vaccinesMight anything help & what are the possible risks? pic.twitter.com/ehpqEX8gwp
— Cochrane UK (@CochraneUK) March 21, 2022
Genotipagem rápida no local de atendimento para evitar a ototoxicidade induzida por aminoglicosídio na UTI neonatal.
23 Mar, 2022 | 11:27hEditorial: Genetic Testing in Newborns Moves From Rare to Routine Application
Comentário no Twitter
The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity
The MT-RNR1 POCT was able to genotype the m.1555A>G variant in 26 minutes. #IDTwitter #medtwitter #TwitteRx #MedEd #PIDTwitter https://t.co/BbkpNMiNHN— Antibiotic Steward Bassam Ghanem🆔🔥 (@ABsteward) March 21, 2022
Estudo randomizado | Contezolida oral vs. linezolida em adultos com infecções cutâneas e de partes moles complicadas.
21 Mar, 2022 | 15:58hA Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections – Journal of Antimicrobial Therapy (link para o resumo – $ para o texto completo)
Comentário no Twitter
Phase III efficacy & safety of oral contezolid Vs linezolid in adults with c.SSTIs
📌Non inferior
📌Interestingly:Contezolid demonstrated significant lower incidence thrombocytopenia (0% Wow vs 2.3%) & leucopenia (0.3% vs 3.4%) than linezolid
📌QIDP https://t.co/wSvxUInnkZ— Antibiotic Steward Bassam Ghanem (@ABsteward) March 11, 2022