Estudos Randomizados
Seguimento de longo prazo de estudo randomizado | Fisioterapia é não inferior a meniscectomia artroscópica parcial precoce em pacientes com rompimento meniscal degenerativo.
13 Jul, 2022 | 12:27h
Estudo randomizado | Canabidiol transdérmico adjunto não é melhor que placedo para epilepsia focal resistente a medicamento.
13 Jul, 2022 | 12:26h
Comentário no Twitter
In this randomized clinical trial, transdermal cannabidiol was well-tolerated and safe, but did not decrease seizure frequency at week 12 of the double-blind period among the placebo, 195-mg cannabidiol, and 390-mg cannabidiol treatments. https://t.co/lR3kEzPE5T
— JAMA Network Open (@JAMANetworkOpen) July 8, 2022
Estudo randomizado | Leflunomida vs. azatioprina como terapia de manutenção da nefrite lúpica.
13 Jul, 2022 | 12:23h
Comentário no Twitter
🆕🔥Leflunomide versus azathioprine for maintenance therapy of lupus nephritis
🫘LEF=AZR in maintenance for SLE-LN
🫘Induction with NIH-CYC
🫘Chinese seem to love Lefno
🫘Generalisability difficult
Would have loved an MMF vs LEF#Rheumtwitter #Nephtwitterhttps://t.co/N2gTYISibM pic.twitter.com/nlP2LkSu8c— EnvisionRheumat (@ERheumat) July 5, 2022
Sob licença de http://creativecommons.org/licenses/by-nc/4.0/
Projeto e condução de estudos adaptativos para avaliar intervenções em serviços de saúde e pesquisas de implementação: considerações práticas.
13 Jul, 2022 | 12:08h
Comentário no Twitter
Practical considerations in designing and conducting adaptive #trials to evaluate interventions in #healthservices and implementation research. ▶️ https://t.co/0kGY6nOSza
@jlauffen #MedTwitter #BMJMedicine pic.twitter.com/Dot9XT1KDu
— BMJMedicine (@BMJMedicine) July 11, 2022
Estudo randomizado | Ablação por cateter da taquicardia ventricular monomórfica na cardiomiopatia concomitante a implante de desfibrilador.
12 Jul, 2022 | 11:39h
Comentário no Twitter
#OriginalResearch: In #PAUSE_SCD RCT, early first-line catheter ablation performed concurrent with ICD implantation for monomorphic VT significantly reduced the composite primary outcome of VT recurrence, CV hospitalization, or death @DrRoderickTung https://t.co/ifQvG9A4j5 pic.twitter.com/5WAcPz3Mlm
— Circulation (@CircAHA) May 5, 2022
Estudo randomizado | Albumina 20% vs. plasmalyte em pacientes com cirrose e hipotensão induzida pela sepse.
12 Jul, 2022 | 11:36h
Estudo randomizado | Não jejum vs. jejum para procedimentos de implante de dispositivos eletrônicos cardíacos implantáveis.
12 Jul, 2022 | 11:28hA randomized trial of non-fasting vs. fasting for cardiac implantable electronic device procedures (Fast-CIED Study) – EP Europace (link para o resumo – $ para o texto completo)
Comentário: Non-fasting yields better well-being, safety in patients getting implantable device – Healio (necessário cadastro gratuito)
Comentário de um dos autores no Twitter
The first RCT to assess the benefits of a non-fasting strategy for #ICD/PM implantation has been published today @ESC_Journals
It is my honor to design and conduct this RCT together with Dr. Bode, Dr. Gerhard and @GerdHindricks. Big thanks to the team…https://t.co/YKQXf1YeRa pic.twitter.com/tzq2hel2MJ— Alireza Sepehri Shamloo (@ShamlooSepehri) June 23, 2022
Estudo randomizado | Neuromodulação sacral para disfunção neurogênica do trato urinário inferior.
11 Jul, 2022 | 13:49hSacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction – NEJM Evidence
Comentário no Twitter
Pts with neurogenic lower urinary tract dysfunction had sacral neuromodulators implanted and optimized. They were then randomized to have the device either remain ON or switched OFF for 2 months. The success rate was 76% in the ON group vs 42% in the OFF. https://t.co/dhteW70jXp pic.twitter.com/1c0w8HOMJm
— NEJM Evidence (@NEJMEvidence) July 7, 2022
Estudo randomizado | Efeito da eletroacupuntura sobra a insônia em pacientes com depressão.
11 Jul, 2022 | 13:48hComentário convidado: Effects of Electroacupuncture for Depression-Related Insomnia – JAMA Network Open
Comentário no Twitter
This randomized clinical trial found that an 8-weeek electroacupuncture with standard care improved sleep quality for patients with insomnia and depression, compared with sham acupuncture and/or standard care. https://t.co/nacnxEI4Ik
— JAMA Network Open (@JAMANetworkOpen) July 7, 2022
Estudo randomizado | Cabozantinibe com atezolizumabe vs. sorafenibe para carcinoma hepatocelular avançado.
11 Jul, 2022 | 13:45hComentário convidado: Cabozantinib plus atezolizumab in advanced hepatocellular carcinoma and the role of adjuvant antiviral therapy – The Lancet Oncology (necessário cadastro gratuito)
Comentário no Twitter
In the phase III COSMIC-312 trial in 837 pts with advanced-stage HCC, mPFS was 6.8 vs 4.2 months (HR 0.63; P=.0012) & mOS was 15.4 vs 15.5 months (HR 0.90; P=.44) with cabozantinib+atezolizumab vs sorafenib; mPFS with cabozantinib alone was 5.8 months: https://t.co/eiZEqSxLAr
— NatureRevClinOncol (@NatRevClinOncol) July 6, 2022