Endocrinologia

Diretriz para o tratamento da doença de Graves pediátrica.

11 Fev, 2022 | 13:52h

2022 European Thyroid Association Guideline for the management of pediatric Graves’ disease – European Thyroid Journal

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Estudo randomizado | Tirzepatida subcutânea adicionada a insulina glargina titulada melhora o controle glicêmico de pacientes com diabetes tipo 2.

10 Fev, 2022 | 13:49h

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Editorial: Tirzepatide for Patients With Type 2 Diabetes – JAMA

Comentário: SURPASS-5 Data: Tirzepatide Plus Insulin Glargine Improve Glycemic Control in T2D – AJMC

Conteúdos relacionados:

RCT: In patients with Type 2 Diabetes, Tirzepatide is associated with reduced weight, improved glycemic control, and lower risk of hypoglycemia compared to insulin glargine.

RCT: Once-weekly tirzepatide vs. once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes.

RCT: Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2.

RCT: Tirzepatide yielded greater glycated hemoglobin and body weight reductions compared to Semaglutide 1 mg.

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Recomendações sobre o cuidado do atleta e da pessoa atlética com diabetes.

10 Fev, 2022 | 13:46h

American Medical Society for Sports Medicine Position Statement on the Care of the Athlete and Athletic Person With Diabetes – Clinical Journal of Sport Medicine

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Podcast | Dislipidemia em crianças.

8 Fev, 2022 | 14:35h

#41: The Good, the Bad, and the Fasting: Dyslipidemia with Dr. Stephen Daniels – The Cribsiders Pediatric Medicine

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Diretriz | Tratamento da hipertensão e do bloqueio do sistema renina-angiotensina-aldosterona em adultos com doença renal diabética.

4 Fev, 2022 | 17:22h

Management of hypertension and renin-angiotensin-aldosterone system blockade in adults with diabetic kidney disease: Association of British Clinical Diabetologists and the Renal Association UK guideline update 2021 – BMC Nephrology

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Análise transversal | Aumento do tecido adiposo visceral em adultos está associado a escores cognitivos reduzidos.

4 Fev, 2022 | 16:35h

Evaluation of Adiposity and Cognitive Function in Adults – JAMA Network Open

Comentários:

Excess Body Fat Tied to Lower Cognitive Scores in Adults – HealthDay

Expert reaction to study looking at the association between body fat and cognition in adults – Science Media Centre

 

Comentário no Twitter

In this study, excess body fat was associated with lower cognitive test performance, independent of other cardiovascular risk factors and MRI-detected vascular brain injury cognitive scores. #adiposity https://t.co/xNJbOa8rbK

— JAMA Network Open (@JAMANetworkOpen) February 1, 2022

 

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Revisão | Diagnóstico e tratamento da acromegalia.

4 Fev, 2022 | 16:32h

Diagnosis and Treatment of Acromegaly: An Update – Mayo Clinic Proceedings

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Revisão | Prevenção da aterosclerose a partir da infância.

4 Fev, 2022 | 15:33h

Prevention of atherosclerosis from childhood – Nature Reviews Cardiology (se o acesso a este link for pago, tente este)

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Revisão | Tratamento do risco de doença cardiovascular aumentado após desfechos adversos de gestação.

4 Fev, 2022 | 14:40h

Primary Care–Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review – Journal of General Internal Medicine (se o acesso a este link for pago, tente este)

Comentário: Better management of long-term heart disease risk needed following complicated pregnancies – Boston Medical Center

Ver também: thread from the author on Twitter summarizing the article

Conteúdos relacionados:

A national cohort study in Sweden showed pregnancy complications (preeclampsia or eclampsia, gestational hypertension, gestational diabetes, preterm birth, small for gestational age, and stillbirth) are associated with increased risk of cardiovascular disease later in life.

AHA Scientific Statement | Adverse Pregnancy Outcomes and Cardiovascular Disease Risk

Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions

Cohort Study: Preeclampsia and Cardiovascular Disease

Cohort Study: Cardiovascular Disease After Hypertensive Disorders of Pregnancy Largely Explained by Conventional Cardiovascular Risk Factors (estudos recentes sobre o tema)

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Estudo randomizado | Suplementação de vitamina D para idosos (média de idade: 67 anos) por 5 anos reduziu o risco de doenças autoimunes em 22%. O risco absoluto no grupo em tratamento foi de 0,95% vs. 1,19% no grupo placebo.

31 Jan, 2022 | 08:51h

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial – The BMJ

Comentário: Vitamin D and fish oil supplements may help prevent autoimmune disease, study says – CNN

Conteúdos relacionados:

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

RCT: Vitamin D supplementation is not beneficial for the prevention of cardiovascular disease and cancer.

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

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