Emergências e Terapia Intensiva

Estudo randomizado | Efetividade da fosfomicina no tratamento de infecções de trato urinário por Escherichia coli multirresistente.

14 Mar, 2022 | 13:37h

Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial – JAMA Network Open

Comentários:

The Role of Intravenous Fosfomycin: Finding Our Way Out of Dante’s Forest Dark – JAMA Network Open

Fosfomycin Not Noninferior to Comparators for Bacteremic UTI – HealthDay

‘Forgotten’ antibiotic recovered for resistant bacterial infections – University of Seville

 

Comentário no Twitter

In this RCT, fosfomycin did not demonstrate noninferiority in MDR-E coli bacteremic UTI, mostly due to adverse event-related withdrawals in mITT, but showed efficacy in per protocol analysis. #FORESTtrial @jesusrbano https://t.co/oiPtiQo2XA pic.twitter.com/Q44QQb18cN

— JAMA Network Open (@JAMANetworkOpen) January 13, 2022

 

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Revisão | Lesão renal aguda induzida por medicamentos.

14 Mar, 2022 | 13:27h

Drug-Induced Acute Kidney Injury – Clinical Journal of the American Society of Nephrology

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Tratamento da insuficiência respiratória: tratamento com ventilador 101 e ventilação não invasiva.

14 Mar, 2022 | 13:26h

Management of Respiratory Failure: Ventilator Management 101 and Noninvasive Ventilation – Clinical Journal of the American Society of Nephrology

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Estudo randomizado | Segurança e eficácia de 3 estratégias de nutrição enteral em pacientes com AVC grave.

11 Mar, 2022 | 14:59h

Safety and efficacy of three enteral feeding strategies in patients with severe stroke in China (OPENS): a multicentre, prospective, randomised, open-label, blinded-endpoint trial – The Lancet Neurology (link para o resumo – $ para o texto completo)

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Eficácia e segurança do tratamento não cirúrgico da apendicite aguda não complicada em comparação à apendicectomia: uma revisão abrangente de revisões sistemáticas e metanálises.

11 Mar, 2022 | 14:58h

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Conteúdos relacionados:

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

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Associação entre uso de estatinas e eventos adversos musculoesqueléticos relacionados à daptomicina: uma abordagem mista combinando metanálise e análise de desproporcionalidade.

11 Mar, 2022 | 14:50h

Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis – Clinical Infectious Diseases

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Estudo randomizado | Em pacientes com parada cardíaca refratária fora do hospital, uma estratégia de transporte durante a ressuscitação, ressuscitação cardiopulmonar extracorpórea e estudo invasivo imediato não trouxe melhora significativa para a sobrevida com um desfecho neurológico favorável (OR 1,63; IC 95% 0,93 a 2,85; P = 0,09).

10 Mar, 2022 | 15:55h

Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link para o resumo – $ para o texto completo)

Comentário: Early Invasive Therapy for Out-of-Hospital Cardiac Arrest – American College of Cardiology

 

Comentário no Twitter

In this randomized clinical trial, early intra-arrest transport, extracorporeal CPR, and invasive assessment and treatment did not significantly improve survival with neurologically favorable outcome at 180 days compared with standard resuscitation. https://t.co/qSqWSFFpOF pic.twitter.com/SLu0bGHhq8

— JAMA (@JAMA_current) February 22, 2022

 

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Metanálise de estudos randomizados | Benefícios e prejuízos de anticoagulantes orais diretos e da heparina de baixo peso molecular para a tromboprofilaxia de pacientes submetidos a cirurgia não cardíaca.

10 Mar, 2022 | 15:52h

Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials – The BMJ

 

Comentário no Twitter

Led by Maura Marcucci, network meta-analysis of of 68 surgery #RCT's (45,445 patients; mainly #ortho) found that #DOAC's & #LMWH reduce #VTE but probably increase major bleeding to a similar extent. DOACs probably prevent symptomatic VTE more than #LMWH. https://t.co/7vrgVpfD3s pic.twitter.com/H5Fuq7p1hi

— Kari Tikkinen (@KariTikkinen) March 9, 2022

 

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Perspectiva | Uma vez visto como um tratamento promissor da COVID-19, o plasma convalescente cai em desuso.

10 Mar, 2022 | 15:49h

Once Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA

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Diretriz | Implementação de diretrizes avançadas no período perioperatório, incluindo planos para ressuscitação cardiopulmonar.

10 Mar, 2022 | 15:41h

Implementing advance care plans in the peri-operative period, including plans for cardiopulmonary resuscitation: Association of Anaesthetists clinical practice guideline – Anaesthesia

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