Acesso livre
Acesso livre

Covid-19 (Temas de Saúde Pública)

[Preprint] Em estudo randomizado com 29.949 participantes, a vacina Novavax demonstrou alta eficácia geral (> 90%) na prevenção de Covid-19, e todos os casos moderados a graves ocorreram no grupo placebo.

14 Out, 2021 | 10:55h

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – medRxiv

Comentário: Novel vaccine demonstrates high efficacy for prevention of COVID-19 – News Medical

Contéudos relacionados:

RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.

Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.

(Press release – not published yet) Novavax COVID-19 vaccine demonstrates 90% overall efficacy and 100% protection against moderate and severe disease.

RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.

[Press release – not published yet] Novavax reports 96% efficacy against original strain of COVID-19, 86% efficacy against B.1.1.7 variant, and 55% efficacy against B1.351 variant

New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work

Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant

 

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Revisão sistemática | Taxas de sequelas pós-agudas da infecção por SARS-CoV-2 no curto e no longo prazos.

14 Out, 2021 | 10:53h

Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review – JAMA Network Open

Comentários:

Most COVID-19 survivors have symptoms 6 months on, review finds – CIDRAP

Expert reaction to systematic review on rates of postacute sequelae of SARS-CoV-2 infection (PASC) – Science Media Centre

How many people get ‘long COVID’? More than half, researchers find – Penn State

Conteúdos relacionados:

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (vários artigos sobre o tema)

 

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Como o Covax falhou em sua promessa de vacinar o mundo – “Covax, descrito como ‘ingenuamente ambicioso’ por um especialista, contribuiu com apenas 5% de todas as vacinas administradas globalmente.”

14 Out, 2021 | 10:49h

How Covax failed on its promise to vaccinate the world – The Bureau of Investigative Journalism

Conteúdos relacionados:

Perspective | A beautiful idea: how COVAX has fallen short.

WHO Launches Strategy to Achieve Global Covid-19 Vaccination by mid-2022.

WHO special envoys: To beat Covid, there’s a simple lesson – no one’s safe until everyone’s safe.

Joint COVAX Statement on the Equal Recognition of Vaccines – COVAX urges all government authorities to recognize as fully vaccinated all people who have received COVID-19 vaccines that have been deemed safe and effective by WHO.

WHO COVAX Joint Statement: Call to action to equip COVAX to deliver 2 billion doses in 2021.

Covax: How will Covid vaccines be shared around the world?

OMS recomenda a aplicação da 3ª dose da vacina contra COVID em grupos de mais alto risco.

13 Out, 2021 | 13:43h

WHO advisers recommend 3rd COVID vaccine dose for highest-risk groups – CIDRAP

Ver também: WHO advises additional COVID shot for immunocompromised people – Reuters

Opinião | Lição da COVID: confie no público com verdades concretas.

13 Out, 2021 | 13:42h

COVID lesson: trust the public with hard truths – Nature

 

Comentário do autor no Twitter (fio – clique para saber mais)

 

Uma cartilha sobre o que se sabe a respeito de misturar e combinar vacinas contra Covid.

13 Out, 2021 | 13:40h

A primer on what we know about mixing and matching Covid vaccines – STAT

Conteúdos relacionados:

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

Dados de vida real mostram que filtros eliminam do ar o vírus causador da COVID.

13 Out, 2021 | 13:39h

Real-world data show that filters clean COVID-causing virus from air – Nature

Artigo original: The removal of airborne SARS-CoV-2 and other microbial bioaerosols by air filtration on COVID-19 surge units – medRxiv

 

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Soroconversão e febre são fatores dose-dependentes em um modelo primata não humano de COVID-19 inalatória.

13 Out, 2021 | 13:37h

Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19 – PLOS Pathogens

Comentário: Dose-dependent COVID-19 symptoms – Nature Reviews Microbiology

 

Comentários no Twitter

 

Estudo nacional na Suécia mostra ligação entre vacinação contra COVID e redução na transmissão domiciliar.

13 Out, 2021 | 12:53h

Comunicado de imprensa: Nationwide study shows link between COVID vaccination and reduced household transmission – Umea University

Estudo original: Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members – JAMA Internal Medicine

Conteúdos relacionados:

Review | Prevention of host-to-host transmission by SARS-CoV-2 vaccines.

Study ties COVID vaccines to lower transmission rates.

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England – “the likelihood of household transmission was approximately 40 to 50% lower in households of index patients who had been vaccinated 21 days or more before testing positive than in households of unvaccinated index patients”.

Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose

Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.

Covid-19: a mudança na política da Nova Zelândia é um avanço ou um retrocesso?

13 Out, 2021 | 12:51h

Covid-19: Is New Zealand’s switch in policy a step forward or a retreat? – The BMJ

Conteúdos relacionados:

New Zealand acknowledges it can no longer completely get rid of the coronavirus.

Why we must not allow COVID to become endemic in New Zealand – The Conversation

 

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