Acesso livre
Acesso livre

Clínica Médica

Um estudo de registro na Dinamarca encontrou um risco aumentado de sangramento com a associação de fluconazol sistêmico e apixabam (OR 3,5; 95% IC, 1,4-10,6).

4 Fev, 2022 | 14:26h

Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran – American Journal of Medicine

M-A | A acurácia diagnóstica do tratamento sindrômico da doença ulcerosa genital.

4 Fev, 2022 | 14:24h

The Diagnostic Accuracy of Syndromic Management for Genital Ulcer Disease: A Systematic Review and Meta-Analysis – Frontiers in Medicine

Posicionamento científico | Prevenção da insuficiência cardíaca.

31 Jan, 2022 | 09:04h

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

Apesar da contínua disseminação da Ômicron, alguns países europeus decidiram suspender os protocolos de restrições para Covid-19.

31 Jan, 2022 | 08:58h

England lifts COVID restrictions as omicron threat recedes – Associated Press

Denmark confirms plan to lift Covid-19 restrictions on February 1st – The Local dk

Netherlands lifts toughest Covid curbs with Denmark and France set to follow – The Guardian

Denmark will lift nearly ALL Covid restrictions within days and return to ‘life as we knew it before corona’ after vaccine programme proved a ‘super-weapon’ – despite soaring cases – Daily Mail

 

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FDA interrompe o uso de anticorpos monoclonais que não funcionam contra a Ômicron.

31 Jan, 2022 | 08:56h

FDA halts use of antibody drugs that don’t work vs. omicron – Associated Press

Conteúdo relacionado: Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

Miocardite após vacinação de adolescentes com BNT162b2 em Israel.

31 Jan, 2022 | 08:55h

Myocarditis after BNT162b2 Vaccination in Israeli Adolescents – New England Journal of Medicine

Conteúdos relacionados:

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

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Estudo randomizado | Suplementação de vitamina D para idosos (média de idade: 67 anos) por 5 anos reduziu o risco de doenças autoimunes em 22%. O risco absoluto no grupo em tratamento foi de 0,95% vs. 1,19% no grupo placebo.

31 Jan, 2022 | 08:51h

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial – The BMJ

Comentário: Vitamin D and fish oil supplements may help prevent autoimmune disease, study says – CNN

Conteúdos relacionados:

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

RCT: Vitamin D supplementation is not beneficial for the prevention of cardiovascular disease and cancer.

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

Revisão sistemática | Dietas com baixo carboidrato vs. dietas com carboidrato equilibrado para redução de peso e de risco cardiovascular.

31 Jan, 2022 | 08:49h

Low‐carbohydrate versus balanced‐carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

Resumo: Low-carbohydrate diets or balanced-carbohydrate diets: which works better for weight loss and heart disease risks? – Cochrane Library

Comentário: Featured review: Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

 

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Diretrizes práticas da ESPEN | Nutrição enteral domiciliar.

31 Jan, 2022 | 08:46h

ESPEN practical guideline: Home enteral nutrition – Clinical Nutrition

 

Resumo de diretriz | Tratamento dos 10 eventos adversos imunológicos mais comuns em pacientes em imunoterapia.

31 Jan, 2022 | 08:39h

Management of the Top 10 Most Common Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy – JCO Oncology Practice

Artigo original: ASCO Guideline Update: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

Conteúdos relacionados:

Clinical practice guideline on immune checkpoint inhibitor-related adverse events.

NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (várias fontes sobre o tema)

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