Clínica Médica

Diretrizes baseadas em evidência sobre interações medicamentosas entre fármacos anticâncer: uma ferramenta prática e universal para o manejo.

14 Abr, 2022 | 17:01h

Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management – Seminars in Oncology

Opinião | Alinhando os incentivos para melhorar a excelência diagnóstica.

14 Abr, 2022 | 16:56h

Aligning Incentives for Improving Diagnostic Excellence – JAMA (gratuito por tempo limitado)

M-A | Efeito clínico e segurança das novas diretrizes sobre o tempo de jejum pré-operatório para cirurgias eletivas.

14 Abr, 2022 | 16:54h

The clinical effect and safety of new preoperative fasting time guidelines for elective surgery: a systematic review and meta-analysis – Gland Surgery

Conteúdos relacionados:

An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children – Anaesthesia

Does my hospitalized patient need an NPO-after-midnight order preoperatively?

ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children.

Editorial: The rationale for the recommendations of the European Pediatric Fasting Guideline – “the authors of the 2021 ESAIC pediatric guideline have found reasons to recommend reductions to the minimum fasting times for infant formula to 4 h, for breast milk to 3 h and for clear fluids to 1 h”.

Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration

Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology

Clear fluids fasting for elective paediatric anaesthesia: The European Society of Anaesthesiology consensus statement – European Journal of Anaesthesiology

Canadian Pediatric Anesthesia Society statement on clear fluid fasting for elective pediatric anesthesia – Canadian Journal of Anesthesia (gratuito)

Mais dados sugerem que a variante Ômicron causa doença mais leve em comparação à variante Delta.

14 Abr, 2022 | 16:51h

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study – The Lancet

Comentário: Covid-19: Symptomatic infection with omicron variant is milder and shorter than with delta, study reports – The BMJ

Conteúdos relacionados:

Another study suggests a lower risk of hospitalization and death from infection with SARS-CoV-2 Omicron variant vs. Delta.

Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa.

Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.

[Preprint] Study showed reduced clinical severity of Covid-19 patients admitted to hospitals in Gauteng, South Africa, during the Omicron-dominant fourth wave – “any combination of a less-virulent virus, comorbidities, high immunity from prior infection(s) or vaccination may be important contributors to this clinical presentation”.

Early data from South Africa hints Omicron variant may cause less severe Covid, but more research is needed.

Too early to tell, but preliminary information from doctors in South Africa suggests the new Covid variant Omicron may be associated with less severe disease.

Aspirina para prevenção cardiovascular primária em pacientes com diabetes: incertezas e oportunidades.

14 Abr, 2022 | 16:43h

Aspirin for Primary Cardiovascular Prevention in Patients with Diabetes: Uncertainties and Opportunities – Thrombosis and Haemostasis

Diretriz relacionada: USPSTF draft statement revises previous guidance and now recommends against initiating low-dose aspirin use for the primary prevention of CVD in adults aged 60 years or older.

Estudos randomizados relacionados:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Metanálises relacionadas:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Opiniões relacionadas:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

Empiema: apresentação em departamento de emergência, avaliação e tratamento.

14 Abr, 2022 | 16:38h

Empyema: ED Presentation, Evaluation, and Management – emDocs

Estudo de coorte | Insônia está associada a risco aumentado de eventos cardiovasculares recorrentes em pacientes com doença cardíaca coronariana.

14 Abr, 2022 | 16:35h

Insomnia as a predictor of recurrent cardiovascular events in patients with coronary heart disease – Sleep Advances

Comentário: Insomnia is linked with recurrent heart events in coronary patients – European Society of Cardiology

Visão geral dos critérios diagnósticos e epidemiologia da lesão renal aguda e da doença renal aguda em pacientes críticos.

14 Abr, 2022 | 16:30h

Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient – Clinical Journal of the American Society of Nephrology

Revisão | Doença pulmonar intersticial induzida por medicamentos.

14 Abr, 2022 | 16:29h

Drug-induced interstitial lung disease – European Respiratory Review

Conteúdo relacionado: Systematic Review: Drug-Induced Interstitial Lung Disease

Doença pulmonar intersticial induzida por medicamentos durante terapias oncológicas: opinião de especialista sobre diagnóstico e tratamento.

14 Abr, 2022 | 16:28h

Drug-induced interstitial lung disease during cancer therapies: expert opinion on diagnosis and treatment – ESMO Open