Acesso livre
Acesso livre

Alergia e Imunologia

Estudos: proteção da vacina diminui com o tempo em relação à infecção por COVID, mas a proteção contra hospitalização é duradoura.

19 Ago, 2021 | 12:27h

Studies: COVID vaccine protection waning against infection but not hospitalization – CIDRAP

Estudo 1: Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults — United States, March–July 2021 – CDC Morbidity and Mortality Weekly Report

Estudo 2: Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021 – CDC Morbidity and Mortality Weekly Report

Estudo 3: New COVID-19 Cases and Hospitalizations Among Adults, by Vaccination Status — New York, May 3–July 25, 2021 – CDC Morbidity and Mortality Weekly Report

 

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Estudo laboratorial mostra que a vacinação heteróloga AstraZeneca/Pfizer produz uma forte resposta imune contra a variante delta do SARS-CoV-2.

18 Ago, 2021 | 13:06h

SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S/BNT162b2 vaccination – The Lancet

Conteúdos relacionados:

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (vários artigos sobre o tema)

 

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FDA autoriza aplicação de dose adicional da vacina contra Covid-19 em indivíduos imunocomprometidos – As demais pessoas, já plenamente vacinadas, não precisam de dose adicional neste momento.

16 Ago, 2021 | 12:10h

Coronavirus (COVID-19) Update: FDA Authorizes Additional Vaccine Dose for Certain Immunocompromised Individuals – U.S. Food & Drug Administration

Comentários:

Statement on FDA Authorization of Supplemental Vaccine Dose for Immunocompromised Patients – Infectious Diseases Society of America

CDC, FDA recommend COVID booster for immune-compromised – CIDRAP

FDA authorizes additional dose of Covid-19 vaccine for the immunocompromised – STAT

The fine print: Understanding the new policy authorizing extra Covid vaccine doses for the immunocompromised – STAT

Covid booster: US approves third jab for the immunocompromised – BBC

CDC Committee Approves Third Covid-19 Shot For Immunocompromised People—Here’s Who Should Get One – Forbes

CDC Panel Recommends 3rd Vaccine Dose For Immunocompromised People – NPR

6 Things To Know If You’re Immunocompromised And Considering A 3rd Shot – NPR

CDC recommends third Covid-19 vaccine dose for certain immunocompromised people – CNN

 

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Estudo sugere um potencial benefício de proteção das vacinas MMR e DTP na redução do risco de infecções graves por Covid-19.

16 Ago, 2021 | 11:56h

Protective heterologous T cell immunity in COVID-19 induced by the trivalent Measles-Mumps-Rubella and Tetanus-Diptheria-Pertussis vaccine antigens – Med

 

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Opinião | Hora de uma abordagem inteligente das doses de reforço.

13 Ago, 2021 | 12:20h

Time for a Smart Approach to Boosters – Think Global Health

Estudo randomizado | Avaliação da vacina de mRNA da Moderna em adolescentes.

12 Ago, 2021 | 12:30h

Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents – New England Journal of Medicine

Conteúdos relacionados:

Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years.

RCT: Pfizer-BioNTech Covid-19 vaccine shows 100% efficacy in adolescents – mainly transient mild-to-moderate reactogenicity was frequently observed, such as injection-site pain (in 79 to 86% of participants), fatigue (in 60 to 66%), and headache (in 55 to 65%).

 

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Estudo randomizado | Terceira dose da vacina de mRNA da Moderna aumenta a imunidade em receptores de transplantes.

12 Ago, 2021 | 12:28h

Randomized Trial of a Third Dose of mRNA-1273 Vaccine in Transplant Recipients – New England Journal of Medicine

Editorial: Third Time’s a Charm — Covid-19 Vaccine Hope for Solid-Organ Transplant Recipients

Conteúdos relacionados:

Study: Among kidney transplant recipients who did not respond after 2 doses, a third dose of an mRNA-1273 vaccine induced a serologic response in 49% of patients.

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

[Preprint] 3rd AstraZeneca shot gives strong immunity.

 

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Características clínicas da trombocitopenia e da trombose imunes induzidas por vacina.

12 Ago, 2021 | 12:21h

Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis – New England Journal of Medicine

Comentário: Largest Study of VITT After COVID-19 Vaccination Digs Into Lab, Clinical Features – TCTMD

Conteúdos relacionados:

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (vários artigos e fontes sobre o tema)

 

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Diretriz | Diagnóstico e tratamento do lúpus cutâneo – Terapia, fatores de risco e outros tópicos.

12 Ago, 2021 | 12:11h

S2k guideline: Diagnosis and management of cutaneous lupus erythematosus – Part 2: Therapy, risk factors and other special topics – Journal of German Society of Dermatology

Breve revisão | Doenças bolhosas imunes.

12 Ago, 2021 | 11:54h

Immunobullous disease – Clinical Medicine Journal

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