Soroconversão e febre são fatores dose-dependentes em um modelo primata não humano de COVID-19 inalatória.

Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19 – PLOS Pathogens

Comentário: Dose-dependent COVID-19 symptoms – Nature Reviews Microbiology

Comentários no Twitter

When exposed to #SARSCoV2 why does one person have no illness, while another is soon in ICU?
Dose.
Controlled study in monkeys shows the dose of viruses inhaled is a key factor determining the severity of the disease.
Seems obvious, yet this is new.https://t.co/zdfCnR40bR pic.twitter.com/HH8kxMM2xm

— Laurie Garrett (@Laurie_Garrett) October 11, 2021

In summer of 2020, our group had proposed a hypothesis that SARS-CoV-2 viral dose or "inoculum" was associated with severity of symptoms in COVID (and proposed NPIs reduced the dose). There is now an experimental model showing this in cynomolgus monkeys:https://t.co/dXGDPyPBFZ

— Monica Gandhi MD, MPH (@MonicaGandhi9) October 12, 2021