Revisão sistemática | Segurança e eficácia da metformina em pacientes com função renal reduzida – Segurança e benefício em taxas de filtração glomerular estimada (estimated glomerular filtration rate – eGFR) de 45 mL/min/1,73 m2 ou mais; possivelmente prejudicial em eGFR abaixo de 30 mL/min/1,73 m2.

Safety and effectiveness of metformin in patients with reduced renal function: A systematic review – Diabetes, Obesity and Metabolism

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Safety of metformin for T2 diabetes in people with reduced kidney function

Associated with ⬇️ mortality and no ⬆️ risk of acidosis at an eGFR of > 45 

Associated with fewer benefits & possible ⬆️ in the risk of acidosis at an eGFR <30 https://t.co/uOyarn11hM@goKDIGO pic.twitter.com/Ca05gc7FHi

— Kamlesh Khunti (@kamleshkhunti) June 16, 2021