Opinião | COVID ESTEROIDE-2: dobro de esteroide, dobro de diversão? – “Dexametasona na dose de 6 mg/dia isoladamente parece ser subótima para a maioria dos pacientes com pneumonia por COVID. Já na dose de 12 mg/dia parece fornecer uma imunomodulação de intensidade razoável.”

COVID STEROID-2: Double the steroid, double the fun? – PulmCrit

Estudo original: RCT: In adults with Covid-19 and severe hypoxemia, 12 mg vs. 6 mg of Dexamethasone did not result in a statistically significant difference in the number of days alive without life support.

Comentário no Twitter

COVID-STEROID 2
🥈5% lower mortality with 12 mg dexamethasone (vs 6 mg) – which is *huge* – but p=0.09 😩
🥈RCTs with toci/bari show that 6 mg dex alone is suboptimal.
🥈If using dex monotherapy, 12 mg is now a sensible dose for sicker pts.
Fresh blog: https://t.co/oPz7vAYHGN pic.twitter.com/diDqqUxSTC

— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) October 23, 2021