M-A | Magnitude da resposta ao placebo entre as modalidades de tratamento usadas para a depressão resistente em adultos.

Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults: A Systematic Review and Meta-analysis – JAMA Network Open

Comentário convidado: Treatment-Resistant Depression—Resistant to Placebos as Well? – JAMA Network Open

Comentário no Twitter

This systematic review and meta-analysis found that in studies of patients with treatment-resistant depression, the placebo effect was large and consistent despite the modality use. https://t.co/U6efJo7rJ8

— JAMA Network Open (@JAMANetworkOpen) September 24, 2021

Important systematic review study: The placebo effect in clinical trials of depression, even if treatment-resistant, is huge!

Magnitude of the Placebo Response Across Treatment-Resistant Depression in Adults https://t.co/ey2hIpE61r via @JAMANetworkOpen part of @JAMANetwork

— Yasser Ad-Dab'bagh (@yasseraddabbagh) September 25, 2021

Question
Why does research on 'treatment resistance' have such high placebo response?

3 Answers
1)Research patients arent nearly as sick as patients in clinical practice
2)Research patients get much more attention than clinical patients
3)Research raises very high expectations https://t.co/f8CyTpKofV

— Allen Frances (@AllenFrancesMD) September 26, 2021

(fio – clique para saber mais)

The paradox of "treatment resistance" in psychiatry that doesn't seem to generate much discussion: if the depression is so treatment resistant that we are considering things like invasive brain stimulation, how come it responds to "placebo" so robustly?/1https://t.co/oQOBPXtVXO

— Awais Aftab (@awaisaftab) September 26, 2021