Estudo randomizado | Não há diferença nos desfechos cardiovasculares com doses noturnas vs. matutinas dos anti-hipertensivos comuns.

Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial – The Lancet

Conteúdo relacionado: [News release – not published yet] #ESCCongres – RCT | Evening dosing of blood pressure medication not better than morning dosing.

Diretriz de consenso relacionada: Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension – Journal of Hypertension

Estudo relacionado (resultados conflitantes): Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction in Randomized Trial