Estudo randomizado | Em pacientes com dor neuropática diabética, a amitriptilina suplementada com pregabalina, a pregabalina suplementada com amitriptilina e a duloxetina suplementada com pregabalina foram similarmente efetivas.

Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial – The Lancet