Estudo randomizado | Efeito da otimização de doses com base no monitoramento medicamentoso de piperacilina/tazobactam na disfunção de órgão relacionada a sepse em pacientes sépticos.

Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial – Intensive Care Medicine

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Therapeutic drug monitoring‑guided pip/tazo infusion vs fixed dose in #sepsis, TARGET RCT:
🧪no significant difference in mean SOFA
⬇️28-day mortality + ⬆️ clinical/microbiological cure if TDM (no statistical significance)
Results https://t.co/cLS1OQ173I
⬇️Below visual abstract pic.twitter.com/jRjzfNLj1T

— Intensive Care Medicine (@yourICM) March 1, 2022