Estudo de coorte | Uso paterno de metformina antes da concepção está associado a risco aumentado de problemas congênitos nos descendentes.

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link para o resumo – $ para o texto completo)

Comentários:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre