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Arquivos do dia: Abril 8, 2022

Estudo mostra risco aumentado de embolia pulmonar em até 110 dias após a COVID-19.

8 Abr, 2022 | 21:58h

Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study – The BMJ

Comunicado de imprensa: Study finds increased risk of serious blood clots up to six months after COVID-19 – BMJ

Editorial: Thromboembolism and bleeding after covid-19

Comentário: Covid: Blood clot risk higher for six months after having virus – BBC

COVID-19: diretriz conjunta do ECDC e EMA sobre a 4ª dose de vacinas de mRNA.

8 Abr, 2022 | 21:56h

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines –
European Centre for Disease Prevention and Control

Conteúdos relacionados:

Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

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Estudo randomizado pragmático | Em pacientes ambulatoriais com COVID-19, a adição da oximetria de pulso para monitoramento não melhorou os desfechos em comparação a avaliações subjetivas isoladas da dispneia.

8 Abr, 2022 | 21:54h

Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial – New England Journal of Medicine

 

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M-A | Fluvoxamina no tratamento ambulatorial da COVID-19 para evitar internação.

8 Abr, 2022 | 21:52h

Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis – JAMA Network Open

Comentário: Common Antidepressant Likely Cuts Risk Of Covid Hospitalization, Study Finds – Forbes

Conteúdos relacionados:

Short Review: Fluvoxamine for symptomatic outpatients with COVID-19.

Fluvoxamine for Covid-19: What Prescribers and Pharmacists Need to Know.

Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.

RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

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Estudo randomizado | Entre pacientes com infecção complicada de trato urinário, o uso oral de tebipenem pivoxil hidrobromida foi não inferior ao ertapenem intravenoso e mostrou perfil de segurança similar.

8 Abr, 2022 | 21:50h

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection – New England Journal of Medicine (link para o resumo – $ para o texto completo)

 

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Opinião | Auditoria dos algoritmos médicos.

8 Abr, 2022 | 21:49h

The medical algorithmic audit – The Lancet Digital Health

Artigo relacionado: Validation and algorithmic audit of a deep learning system for the detection of proximal femoral fractures in patients in the emergency department: a diagnostic accuracy study – The Lancet Digital Health

Conteúdo relacionado: Health-related artificial intelligence needs rigorous evaluation and guardrails – STAT

 

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Estudo randomizado | Eficácia de longo prazo e segurança da denervação renal na presença de medicamentos anti-hipertensivos.

8 Abr, 2022 | 21:47h

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial – The Lancet (link para o resumo – $ para o texto completo)

Comentário: Three-year trial of SPYRAL HTN-ON MED shows blood pressure reductions – MedicalXpress

Conteúdos relacionados:

Systematic Review: Renal denervation may have a modest effect in improving 24h ambulatory blood pressure monitoring (reduction in SBP by 5.29 mmHg and DBP by 3.75 mmHg) but does not improve major cardiovascular outcomes and renal function.

M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.

Meta-Analysis: Sham-Controlled Randomized Trials of Catheter-Based Renal Denervation in Patients with Hypertension

 

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Estudo randomizado | Efeito de diferentes esquemas de doses de corticosteroides sobre os desfechos clínicos em meninos com distrofia muscular de Duchenne.

8 Abr, 2022 | 21:46h

Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial – JAMA (gratuito por tempo limitado)

Conteúdos relacionados:

RCT: Routine lung volume recruitment is not beneficial for boys with Duchenne muscular dystrophy.

Phase 2 RCT: Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy.

Research: Long-term effects of glucocorticoids in patients with Duchenne muscular dystrophy

 

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Perspectiva | Um roteiro equitativo para acabar com a pandemia de COVID-19.

8 Abr, 2022 | 21:43h

An equitable roadmap for ending the COVID-19 pandemic – Nature Medicine

 

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Perspectiva | Como estudar a COVID longa grave para compreender os distúrbios pós-infecciosos além da COVID-19.

8 Abr, 2022 | 21:42h

Studying severe long COVID to understand post-infectious disorders beyond COVID-19 – Nature Medicine

Conteúdos relacionados:

Review: Post-acute COVID-19 syndrome.

ESCMID rapid guidelines for assessment and management of long COVID.

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (vários artigos sobre o tema)

2022 ACC expert consensus decision pathway on cardiovascular sequelae of COVID-19 in adults: myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play.

Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

 

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