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Arquivos do dia: Fevereiro 14, 2022

Nova Classificação Internacional de Doenças (CID-11) da OMS entra em vigor.

14 Fev, 2022 | 16:18h

Comunicado de imprensa: WHO’s new International Classification of Diseases (ICD-11) comes into effect – World Health Organization

Ver também:

ICD-11 Browser

ICD-11 website

ICD-11 coding tool

 

Comentário no Twitter

 

Novavax afirma que vacina proteica funciona para crianças a partir dos 12 anos de idade.

14 Fev, 2022 | 16:16h

Novavax says protein vaccine works for kids as young as 12 – Associated Press

Comunicado de imprensa: Novavax Announces Positive Results of COVID-19 Vaccine in Pediatric Population of PREVENT-19 Phase 3 Clinical Trial

Conteúdos relacionados:

Randomized trial with nearly 30.000 individuals showed Novavax vaccine was safe and had an overall efficacy of 90.4% against symptomatic infections.

RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.

Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.

(Press release – not published yet) Novavax COVID-19 vaccine demonstrates 90% overall efficacy and 100% protection against moderate and severe disease.

RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.

[Press release – not published yet] Novavax reports 96% efficacy against original strain of COVID-19, 86% efficacy against B.1.1.7 variant, and 55% efficacy against B1.351 variant

New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work

Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant

Pfizer e FDA recuam em relação ao plano para agilizar a avaliação de vacinas contra Covid-19 em crianças menores de 5 anos.

14 Fev, 2022 | 16:14h

Pfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in young children – STAT

Ver também:

COVID-19 vaccine for kids under 5 delayed as Pfizer extends trial – CIDRAP

Pfizer postpones FDA request for Covid vaccine for kids under 5 – NBC News

Estudos conflitantes levantam questões sobre se algum anticorpo monoclonal funciona contra a variante “irmã” da Ômicron.

14 Fev, 2022 | 16:13h

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant – STAT

Conteúdos relacionados:

FDA halts use of antibody drugs that don’t work vs. Omicron.

Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

Diretriz ERS | Seguimento de “long COVID-19”.

14 Fev, 2022 | 16:11h

European Respiratory Society Statement on Long COVID-19 Follow-Up – European Respiratory Review

Primeira definição para “long Covid” em crianças e jovens é formalmente elaborada.

14 Fev, 2022 | 16:10h

Comunicado de imprensa: First research definition for ‘Long COVID’ in kids and young people formally agreed – BMJ

Artigo original (preprint): Long COVID (Post-COVID-19 condition) in Children: a modified Delphi Process – Archives of Disease in Childhood

Comentários:

Expert reaction to Delphi consensus study on a long-COVID definition in children – Science Media Centre

Long covid: “Holistic” approach is best, given range of symptoms, say researchers – The BMJ

Conteúdos relacionados:

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Covid-19: o que se sabe sobre as sublinhagens da Ômicron?

14 Fev, 2022 | 16:08h

Covid-19: What do we know about omicron sublineages? – The BMJ

Conteúdos relacionados:

We regret to inform you that we are now discussing subvariants – Vox

Sudden rise of more transmissible form of Omicron catches scientists by surprise.

Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first?

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation

 

Comentário no Twitter

 

Edição especial | Estratégias baseadas em evidências para melhor prescrição de antibióticos na atenção primária.

14 Fev, 2022 | 16:07h

Editorial: Antibiotic stewardship – Australian Journal of General Practice

Antibiotic stewardship: A review of successful, evidence-based primary care strategies – Australian Journal of General Practice

Evidence-based strategies for better antibiotic prescribing – Australian Journal of General Practice

How can general practitioners reduce antibiotic prescribing in collaboration with their patients? – Australian Journal of General Practice

Estudo randomizado | Profilaxia primária com norfloxacino evita infecções bacterianas em pacientes com insuficiência hepática crônica agudizada.

14 Fev, 2022 | 16:05h

Primary Norfloxacin Prophylaxis for APASL-Defined Acute-on-Chronic Liver Failure: A Placebo-Controlled Double-Blind Randomized Trial – The American Journal of Gastroenterology (link para o resumo – $ para o texto completo)

Estudo randomizado | Efeitos de 6 meses de uma dieta de baixo carboidrato sobre controle glicêmico, composição corporal e fatores de risco cardiovascular em pacientes com diabetes tipo 2.

14 Fev, 2022 | 16:03h

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

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