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Arquivos do dia: Novembro 8, 2021

Comunicado de imprensa – ainda não publicado] Estudo randomizado | Novo antiviral oral da Pfizer, candidato a tratamento da Covid-19, reduziu o risco de internação ou morte em 89% em análise interina da fase 2/3 do estudo EPIC-HR.

8 Nov, 2021 | 12:47h

Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR Study

Comentários:

Expert reaction to press release from Pfizer giving interim analysis of their Phase 2/3 EPIC-HR study of PAXLOVID™ in non-hospitalized high-risk adults with COVID-19 – Science Media Centre

Pfizer’s Good News Is the World’s Good News – Science

Experimental Pfizer pill prevents Covid hospitalizations and deaths – STAT

Pfizer Says New Anti-Viral Drug Combination Cuts Risks Of Serious COVID-19 By 89% – Health Policy Watch

Pfizer reports good results against severe COVID-19 for its antiviral pill – CIDRAP

Covid: Pfizer says antiviral pill 89% effective in high-risk cases – BBC

Pfizer says COVID-19 pill cut hospital, death risk by 90% – Associated Press

Pfizer’s COVID-19 pill treatment reduces risk of being hospitalized or dying by 89%, company says – ABC News

 

Comentário no Twitter (fio – clique para saber mais)

 

[Ainda não publicado] Farmacêutica Sinovac afirma que sua vacina contra Covid-19 é segura para crianças e mesmo bebês a partir dos 6 meses de vida.

8 Nov, 2021 | 12:45h

Chinese drug firm Sinovac says Covid-19 vaccine safe for children, babies as young as six months old; submits data to Hong Kong government – South China Morning Post

Conteúdos relacionados:

Randomized phase 1/2 trial: Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in children and adolescents aged 3–17 years.

Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years.

Ponto de vista | Vacinas contra COVID-19 na pediatria: o que pais, médicos e formadores de políticas públicas precisam saber.

8 Nov, 2021 | 12:43h

Pediatric COVID-19 Vaccines: What Parents, Practitioners, and Policy Makers Need to Know – JAMA

Miocardite após vacina de mRNA contra COVID-19: uma série de casos e a determinação das taxas de incidência.

8 Nov, 2021 | 12:41h

Myocarditis Following COVID-19 mRNA Vaccine: A Case Series and Incidence Rate Determination – Clinical Infectious Diseases

Conteúdos relacionados:

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

Vacinação contra COVID-19 em gestantes, crianças, pacientes imunocomprometidos, pessoas com histórico de alergia ou infecção prévia por SARS-CoV-2: visão geral das recomendações atuais e evidências pré e pós-marketing da eficácia e da segurança das vacinas.

8 Nov, 2021 | 12:40h

COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety – Drug Safety

Ponto de vista | Crianças e COVID-19 nas escolas.

8 Nov, 2021 | 12:38h

Children and COVID-19 in schools – Science

Conteúdos relacionados:

Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay.

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – “Test-to-stay could dramatically reduce close contact quarantines”.

Opinion | Data from routine Covid testing can help schools stay open this year.

CDC Report: Schools without mask requirements were more likely to have Covid-19 outbreaks.

Perspective | Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain.

COVID and schools: the evidence for reopening safely.

COVID studies note online learning stress, fewer cases in schools with protocols

Alemanha oferece doses de reforço de vacina contra Covid-19 a todos em meio a um aumento de casos “muito preocupante”.

8 Nov, 2021 | 12:37h

Germany offers booster shots to everyone amid ‘very worrying’ surge in cases – CNN

Estudo randomizado | Em pacientes com doença renal crônica avançada e hipertensão mal controlada, a clortalidona teve um impacto significativo no controle da pressão arterial (-11 mmHg vs. -0,5 mmHg no grupo placebo).

8 Nov, 2021 | 12:35h

Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comentário: Cheap Diuretic, Chlorthalidone, Drops BP in Advanced Kidney Disease – Medscape (necessário cadastro gratuito)

 

Comentário no Twitter

 

Estudo randomizado | Em pacientes com doença renal crônica e anemia em tratamento dialítico, a medicação oral daprodustate foi não inferior a darbepoetina alfa em aumentar os níveis de hemoglobina e também em relação aos desfechos cardiovasculares.

8 Nov, 2021 | 12:33h

Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comunicado de imprensa: Oral pill as safe, efficacious as conventional treatment for anemia in patients with kidney disease – Brigham and Women’s Hospital

 

Comentário no Twitter

 

Estudo randomizado | Em pacientes com doença renal crônica e anemia que não estão sendo submetidos a diálise, a medicação oral daprodustate foi não inferior a darbepoetina alfa em aumentar os níveis de hemoglobina e também em relação aos desfechos cardiovasculares.

8 Nov, 2021 | 12:32h

Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis – New England Journal of Medicine (link para o resumo – $ para o texto completo)

Comunicado de imprensa: Oral pill as safe, efficacious as conventional treatment for anemia in patients with kidney disease – Brigham and Women’s Hospital

 

Comentário no Twitter

 

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