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Arquivos do dia: Outubro 27, 2021

Painel consultivo do FDA recomenda que a vacina da Pfizer contra a Covid-19 seja autorizada para crianças de 5 a 11 anos de idade.

27 Out, 2021 | 12:44h

FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children – STAT

Ver também:

Tracking the FDA advisory panel meeting on Covid-19 vaccines for kids – STAT

FDA advisory panel recommends Pfizer vaccine for kids ages 5 to 11 – NPR

Covid-19 em indivíduos já vacinados ocorre com mais frequência naqueles com baixos níveis de anticorpos.

27 Out, 2021 | 12:42h

Breakthrough Infections Occur in Those with Lower Antibody Levels, Israeli Study Shows – NIH Director’s Blog

Estudo original: Covid-19 Breakthrough Infections in Vaccinated Health Care Workers – New England Journal of Medicine

Vacinação heteróloga AstraZeneca/Pfizer parece estar associada com maior efetividade contra Covid-19 em comparação com a vacinação homóloga Pfizer/Pfizer.

27 Out, 2021 | 12:41h

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination – Nature

Conteúdos relacionados:

Cohort Study: The effectiveness of heterologous AstraZeneca (AZ)/mRNA prime-boost vaccination was more significant (68%) compared to the effectiveness of homologous AZ/AZ vaccination (50%) against symptomatic Covid-19 infection in Sweden.

Should You Mix and Match Your Booster Shot?

Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.

A primer on what we know about mixing and matching Covid vaccines.

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

 

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Diferentes vacinas contra COVID misturadas e combinadas com sucesso no teste de efetividade – “Não é preciso se restringir a nenhuma marca.”

27 Out, 2021 | 12:39h

Mix-and-match COVID vaccines ace the effectiveness test – Nature

Conteúdos relacionados:

Cohort Study: The effectiveness of heterologous AstraZeneca (AZ)/mRNA prime-boost vaccination was more significant (68%) compared to the effectiveness of homologous AZ/AZ vaccination (50%) against symptomatic Covid-19 infection in Sweden.

Should You Mix and Match Your Booster Shot?

Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.

A primer on what we know about mixing and matching Covid vaccines.

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

Superimunidade contra COVID: um dos maiores desafios da pandemia – “Pessoas que se recuperaram da COVID-19 apresentaram resposta imunológica mais forte após serem vacinadas do que pessoas não previamente infectadas. Cientistas tentam descobrir o motivo.”

27 Out, 2021 | 12:37h

COVID super-immunity: one of the pandemic’s great puzzles – Nature

O que a teoria dos jogos pode ensinar sobre o controle de pandemias.

27 Out, 2021 | 12:36h

What game theory can teach us about controlling pandemics – The BMJ Opinion

 

Comentário no Twitter

 

Bioética | A sugestão de que os negacionistas da Covid fiquem longe dos hospitais públicos da Austrália é terrível.

27 Out, 2021 | 13:21h

The suggestion Covid deniers should stay out of Australian public hospitals is appalling – The Guardian

Atualização de prática clínica da AGA sobre o manejo endoscópico de perfurações no trato gastrintestinal.

27 Out, 2021 | 12:34h

AGA Clinical Practice Update on Endoscopic Management of Perforations in Gastrointestinal Tract: Expert Review – Clinical Gastroenterology and Hepatology

Consenso UEG para dispepsia funcional.

27 Out, 2021 | 12:32h

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia – UEG Journal

Estudo randomizado | Irradiação eletiva de linfonodo mamário interno não aumenta a sobrevida livre de doença ou a sobrevida geral na maioria das mulheres com câncer de mama com linfonodo acometido.

27 Out, 2021 | 12:31h

Effect of Elective Internal Mammary Node Irradiation on Disease-Free Survival in Women With Node-Positive Breast Cancer: A Randomized Phase 3 Clinical Trial – JAMA Oncology (gratuito por tempo limitado)

Comentário: No Survival Benefit for Internal Mammary Node Irradiation in Breast Cancer — Women with medially or centrally located tumors may be candidates, however, says researcher – MedPage Today (necessário cadastro gratuito)

 

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