Arquivos do dia: Outubro 21, 2021

Vacina da Pfizer mostrou efetividade estimada de 93% contra infecção sintomática pela variante Delta do SARS-CoV-2 em adolescentes.

21 Out, 2021 | 11:37h

Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents – New England Journal of Medicine

Conteúdo relacionado: CDC Study: Pfizer vaccine showed 93% effectiveness against Covid-19 hospitalization among children aged 12-18 years.

 

Comentário no Twitter

The remarkably high effectiveness (VE) of vaccination for teens vs the Delta variant in over 94,000 vaccinees and 94,000 matched controls: 93% VE vs symptomatic infection (95% CI 88,97) https://t.co/wwoXlw7PH9@NEJM pic.twitter.com/8m3fJ7avc5

— Eric Topol (@EricTopol) October 20, 2021

 

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Uma análise da mortalidade de 114.000 pessoas infectadas pelo SARS-CoV-2 na Escócia revelou que a efetividade da vacina contra morte pela variante Delta foi de 90% para a Pfizer e 91% para a AstraZeneca.

21 Out, 2021 | 11:35h

BNT162b2 and ChAdOx1 nCoV-19 Vaccine Effectiveness against Death from the Delta Variant – New England Journal of Medicine

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Um estudo de caso-controle mostrou que a vacinação contra Covid-19 no início da gestação não esteve associada a risco aumentado de aborto no primeiro trimestre.

21 Out, 2021 | 11:34h

Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage – New England Journal of Medicine

Conteúdos relacionados:

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

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Pneumonia por COVID-19: fisiopatologia e tratamento.

21 Out, 2021 | 11:30h

COVID-19 pneumonia: pathophysiology and management – European Respiratory Review

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FDA autoriza o uso de doses de reforço das vacinas da Moderna e da Johnson & Johnson, e afirma que misturar e combinar é OK.

21 Out, 2021 | 11:29h

FDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK – CNN

Ver também:

FDA OKs mixing COVID vaccines; backs Moderna, J&J boosters – Associated Press

FDA OKs Moderna, J&J boosters, along with ‘mix and match’ approach – NBC News

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Em vez de quarentena para estudantes expostos à Covid, algumas escolas estão tentando “testar-para-ficar”.

21 Out, 2021 | 11:27h

Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay – CNN

Conteúdos relacionados:

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – “Test-to-stay could dramatically reduce close contact quarantines”.

Opinion | Data from routine Covid testing can help schools stay open this year.

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Diretriz NCCN | Doença tromboembólica venosa associada a câncer.

21 Out, 2021 | 11:25h

Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

Conteúdos relacionados:

ASH 2021 guidelines for prevention and treatment of venous thromboembolism in patients with cancer

Review: venous and arterial thromboembolism in patients with cancer.

Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?

M-A: Extended thromboprophylaxis after hospital discharge for medically ill patients with cancer – Extended thromboprophylaxis is not associated with a reduced rate of venous thromboembolic events and is associated with increased risk of hemorrhage

Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

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Diretriz | Disfunção erétil.

21 Out, 2021 | 11:24h

Canadian Urological Association guideline: Erectile dysfunction – Canadian Urological Association Journal

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Opinião | É hora da Medicina Baseada em Evidências 2.0?

21 Out, 2021 | 11:23h

Is it time for Evidence-Based Medicine 2.0? – Centre for Evidence-Based Medicine

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Opinião | Compreender os resultados de pesquisas, os resumos de evidências e sua aplicabilidade – e não uma avaliação crítica minuciosa – são habilidades fundamentais do currículo médico.

21 Out, 2021 | 11:22h

Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum – BMJ Evidence-Based Medicine

 

Comentário no Twitter

Is the critical appraisal of individual studies a core skill for clinicians? @KariTikkinen and @EBCPMcMaster argue that there are more important things for them to learn in order to apply #EBM in real life.

A thought-provoking piece in @BMJ_EBM 👌https://t.co/f6KvsRpHOw pic.twitter.com/FOf5ywT1bf

— Lucas Morin (@lucasmorin_eolc) October 20, 2021

 

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