Arquivos do dia: Setembro 7, 2021

Intervalos maiores entre as doses e doses de reforço da vacina da AstraZeneca estão associados com aumento da imunogenicidade.

7 Set, 2021 | 22:13h

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002) – The Lancet

Comentário convidado: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine

 

Comentários no Twitter

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Substudy suggests extended interval (up to 45 wks) before 2nd dose of ChAdOx1 nCoV-19 leads to increased antibody titres, offering more flexibility in vaccine schedules.

Extended interval before 3rd dose resulted in further increase in immune responses. https://t.co/J3xOwSSYMN pic.twitter.com/8GotDI4ctS

— The Lancet (@TheLancet) September 2, 2021

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New @TheLancet
The heightened immune response to longer spacing @AstraZeneca 1st -> 2nd vaccine doses and the response 3rd booster dose, with high neutralizing antibodies and T cellshttps://t.co/A2UcPVIFYP pic.twitter.com/zfYaW0T8Yf

— Eric Topol (@EricTopol) September 1, 2021

 

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[Preprint] Amplo estudo de coorte no Brasil mostrou que a vacina da AstraZeneca teve uma alta eficácia geral contra doença grave em indivíduos até 89 anos de idade. Em comparação, a vacina CoronaVac teve alta eficácia geral contra doença grave em indivíduos até 79 anos de idade.

7 Set, 2021 | 22:11h

Influence of age on the effectiveness and duration of protection in Vaxzevria and CoronaVac vaccines – medRxiv

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Relatório CDC | Taxas de hospitalização por Covid-19 foram 10 vezes mais altas entre adolescentes não vacinados do que entre os vacinados.

7 Set, 2021 | 22:09h

Hospitalizations Associated with COVID-19 Among Children and Adolescents — COVID-NET, 14 States, March 1, 2020–August 14, 2021 – CDC Morbidity and Mortality Weekly Report

Comentários:

More kids hospitalized with Covid-19 in states with lower vaccination rates, CDC report finds – CNN

The hospitalization rate among teens who are unvaccinated is 10 times higher than teens who are vaccinated, new CDC data shows – Insider

Child COVID hospital cases up in low-vaccination states – CIDRAP

 

Comentário no Twitter

From late June to mid-August, there was a 10x increase in the rate of hospitalizations among children ages 0-4 with #COVID19 while the #DeltaVariant was widely circulating. It is critical for children to #maskup and get vaccinated if eligible. Learn more: https://t.co/aHC1vYdKVG. pic.twitter.com/uUeNPG6d5r

— CDC (@CDCgov) September 3, 2021

 

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Atualização anual em medicina de emergência e terapia intensiva 2021 – Artigos sobre Covid.

7 Set, 2021 | 22:08h

Secondary infections in critically ill patients with COVID-19

Tracheostomy for COVID-19: evolving best practice

Ver também: Non-Covid articles

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Série de casos | Vacinas mRNA contra COVID levando a inflamação do SNC.

7 Set, 2021 | 22:06h

COVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology

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[Ainda não publicado] Dose de reforço da Sinovac reverte a queda da atividade dos anticorpos contra a variante Delta em estudo.

7 Set, 2021 | 22:05h

Sinovac booster shot reverses drop in antibody activities against Delta-study – Reuters

 

Comentário no Twitter

A booster dose of Sinovac Biotech's COVID-19 vaccine reversed a decline in antibody activities against the Delta variant, a study showed, easing some concerns about its longer-term immune response to the highly contagious strain of the virus. https://t.co/QdmMYVBrvl

— Reuters Health (@Reuters_Health) September 6, 2021

 

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Opinião | Vídeo: imunidade é o único caminho para atravessar uma pandemia (com Dra. Monica Gandhi).

7 Set, 2021 | 22:04h

Immunity Is The Only Way Through A Pandemic (w/Dr. Monica Gandhi) – ZDoggMD

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Atualização anual em medicina de emergência e terapia intensiva 2021 – Artigos não relacionados a Covid.

7 Set, 2021 | 22:02h

Advanced management of intermediate-high risk pulmonary embolism

Pathophysiology and clinical implications of the veno-arterial PCO₂ gap

To prone or not to prone ARDS patients on ECMO

Management of acute metabolic acidosis in the ICU: sodium bicarbonate and renal replacement therapy

Acute kidney injury in ECMO patients

Monitoring and modifying brain oxygenation in patients at risk of hypoxic ischaemic brain injury after cardiac arrest

Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?

Still a place for aortic counterpulsation in cardiac surgery and patients with cardiogenic shock?

Ver também: Covid articles

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Estudo de coorte | Marcadores sorológicos de lesão cerebral podem predizer bom desfecho neurológico após parada cardíaca fora do ambiente hospitalar.

7 Set, 2021 | 22:01h

Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest – Intensive Care Medicine

 

Comentário no Twitter

Established/novel blood brain injury markers early predict good neuro-outcome/absence of pathological prognostic findings post CA
🧠NSE/S100B may prevent premature WLST
🧠NFL highest predictive capacity
Here visual abstract, full results #FOAMcc @yourICM https://t.co/3klcew33bD pic.twitter.com/1agsFCw6RF

— Intens Care Med (@yourICM) September 4, 2021

 

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Alimentação via sonda para pessoas com demência grave: tomada de decisão.

7 Set, 2021 | 21:59h

Tube feeding for people with severe dementia: making decisions – Evidently Cochrane

Artigo original: Systematic review: Enteral tube feeding for people with severe dementia – “We found no evidence that tube feeding improves survival; improves quality of life; reduces pain; reduces mortality; decreases behavioural and psychological symptoms of dementia”.

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