Acesso livre
Acesso livre

Arquivos do dia: Julho 26, 2021

[Preprint] RCT: Em pacientes com COVID-19 e hipóxia grave, a dexametasona 12 mg NÃO resultou em melhora estatisticamente significativa nos desfechos em comparação com a dexametasona 6 mg – “A mortalidade em 28 dias foi de 27,1% e 32,3% em pacientes atribuídos a 12 mg e 6 mg, respectivamente (risco relativo ajustado 0,86, 99% IC, 0,68-1,08).”

26 Jul, 2021 | 10:24h

Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial – medRxiv

Estudo de coorte mostrou que 1 em cada 2 pacientes hospitalizados com COVID-19 desenvolve complicação.

26 Jul, 2021 | 10:23h

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study – The Lancet

Comentários:

Landmark study finds one in two hospitalised COVID-19 patients develop a complication – National Institute for Health Research

In-hospital complications associated with COVID-19 – The Lancet

CV Complications Common in Hospitalized COVID-19 Patients – TCTMD

Almost Half of Patients Admitted With COVID-19 Have Complications – HealthDay

 

Comentário no Twitter (fio – clique para saber mais)

 

Estudo de coorte | Manifestações neurológicas da infecção por SARS-CoV-2 em crianças e adolescentes hospitalizados no Reino Unido – “Em torno de 1 em cada 20 crianças hospitalizadas com COVID-19 desenvolveu complicações neurológicas associadas à infecção viral.”

26 Jul, 2021 | 10:21h

Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study – The Lancet Child & Adolescent Health

Comentários:

Neuroinflammation triggered by SARS-CoV-2 infection: syndromes and therapies – The Lancet Child & Adolescent Health

New UK study reveals extent of brain complications in children hospitalized with COVID-19 – University of Liverpool

 

Comentário no Twitter

 

M-A | Pacientes psiquiátricos têm risco aumentado de hospitalização e morte por COVID-19.

26 Jul, 2021 | 10:20h

Comunicado de imprensa: Psychiatric patients at increased risk of COVID-19 hospitalization and mortality – European College of Neuropsychopharmacology

Artigo original: Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis – The Lancet Psychiatry

Estudo mostra que o teste de antígeno de fluxo lateral pode detectar, de modo rápido e acurado, a COVID-19 inicial em pacientes com sintomas gripais e pode ser uma alternativa plausível ao RT-PCR.

26 Jul, 2021 | 10:19h

Comparing the diagnostic accuracy of point-of-care lateral flow antigen testing for SARS-CoV-2 with RT-PCR in primary care (REAP-2) – EClinicalMedicine

Comunicado de imprensa: Lateral flow tests are 95% effective at detecting Covid-19 when used at the onset of symptoms – University of Oxford

Relacionado:

Interactive Infographic | Interpreting a lateral flow SARS-CoV-2 antigen test – “This calculator demonstrates how interpreting a covid-19 lateral flow device (LFD) result varies according to the pre-test probability, and the sensitivity and specificity of the LFD used”.

Rapid point-of-care tests for diagnosing COVID-19 infection: the latest Cochrane evidence

 

Comentário no Twitter (fio – clique para saber mais)

 

Entre receptores de transplante de rim que não tiveram resposta imune adequada a 2 doses, uma terceira dose de vacina mRNA induziu resposta sorológica em 49% dos pacientes.

26 Jul, 2021 | 10:18h

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses – JAMA

Comentário: Case Mounts for COVID Vaccine Boosters in Kidney Transplant Recipients – MedPage Today (necessário cadastro gratuito)

Relacionado:

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

[Preprint] 3rd AstraZeneca shot gives strong immunity.

 

Comentário no Twitter

 

Relato de caso | Síndrome inflamatória multissistêmica similar a doença de Kawasaki associada a infecção por SARS-CoV-2 em adulto.

26 Jul, 2021 | 10:16h

Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult – BMJ Case Reports

Relacionado:

Case report: Multisystem inflammatory syndrome in an adult after SARS-CoV-2 infection.

Characteristics associated with Multisystem Inflammatory Syndrome among adults with SARS-CoV-2 infection

Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection

Case Reports: 2 Adults with Kawasaki-like Multisystem Inflammatory Syndrome Associated with COVID-19

Vacinas contra COVID talvez cheguem aos países mais pobres somente em 2023 – “Especialistas afirmam que, em meio ao aumento da COVID na África, a promessa de vacinas vindo de nações mais ricas não é suficiente para acabar com a pandemia.”

26 Jul, 2021 | 10:15h

COVID vaccines to reach poorest countries in 2023 — despite recent pledges – Nature

Diretriz da OMS sobre prevenção de afogamento.

26 Jul, 2021 | 10:13h

WHO Guideline on the prevention of drowning through provision of day-care and basic swimming and water safety skills – World health Organization

Ver também: World Drowning Prevention Day 2021 (25 de julho)

Comunicado de imprensa: Drowning is a leading cause of accidental death – United Nations

Relacionado:

AAP Technical Report | Prevention of Drowning.

The Burden of Unintentional Drowning: Global, Regional and National Estimates of Mortality from the Global Burden of Disease Study

Preventing drowning: an implementation guide – World Health Organization

Global report on drowning: preventing a leading killer – World Health Organization

Report: Open Water Drowning and Risks for Children

Wilderness Medical Society Clinical Practice Guidelines for the Treatment and Prevention of Drowning: 2019 Update – Wilderness and Environmental Medicine

 

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Posicionamento Científico | Medicina de precisão na síndrome da angústia respiratória aguda.

26 Jul, 2021 | 10:11h

Advancing precision medicine for acute respiratory distress syndrome – The Lancet Respiratory Medicine

Relacionado:

Review: Personalized mechanical ventilation in acute respiratory distress syndrome.

Seminar | Acute respiratory distress syndrome.

M-A of randomized trials: In patients with acute respiratory distress syndrome, there was no difference in mortality between higher vs. lower positive end-expiratory pressure strategies.

M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS

M-A: Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids

ARDS: Contemporary management and novel approaches during COVID-19

Systematic review: Evidence-based practices for acute respiratory failure and Acute Respiratory Distress Syndrome

Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.

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