Arquivos do dia: Julho 16, 2021
Por que um grande estudo sobre ivermectina para Covid-19 foi excluído da revista onde foi publicado?
16 Jul, 2021 | 10:01hWhy Was a Major Study on Ivermectin for COVID-19 Just Retracted? – Grifter Analysis and Review
Ver também: Huge study supporting ivermectin as Covid treatment withdrawn over ethical concerns – The Guardian E Some problems in the dataset of a large study of Ivermectin for the treatment of Covid-19 – Nick Brown’s Blog E Is Ivermectin for Covid-19 Based on Fraudulent Research? – Gideon M-K; Health Nerd
Comentário no Twitter (fio – clique para saber mais)
So, one of the biggest studies to date on ivermectin for COVID-19 has issues significant enough that, if not fraud, are so serious that it invalidates the study without further explanation
I promised a thread
Here we go 1/n https://t.co/L9QOChmGtA
— Health Nerd (@GidMK) July 16, 2021
Sintomas de longo prazo após infecção por SARS-CoV-2 em crianças e adolescentes – “Este estudo mostra uma baixa prevalência de sintomas compatíveis com ‘long COVID’ em uma coorte de crianças aleatoriamente selecionadas e avaliadas 6 meses após o teste por sorologia.”
16 Jul, 2021 | 09:59hLong-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – JAMA
Perspectiva | Como evitar uma futura injustiça de vacinas.
16 Jul, 2021 | 09:59hAverting Future Vaccine Injustice – New England Journal of Medicine
Comentário no Twitter
As high-income countries have secured much of the #Covid19vaccine supply, many low-income countries have barely begun the immunization process. We need political courage to end vaccine injustice now and political vision to negotiate rules for averting future inequities.
— NEJM (@NEJM) July 15, 2021
Vacinação heteróloga com doses da Oxford–AstraZeneca e da Moderna induz aumento nos níveis de anticorpos neutralizantes em comparação a 2 doses da vacina da Oxford–AstraZeneca.
16 Jul, 2021 | 09:58hHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Relacionado: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. E Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. E RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Comentário no Twitter
Health care workers who had received a dose of ChAdOx1 nCoV-19 were offered either ChAdOx1 nCoV-19 or mRNA-1273 9 to 12 weeks later. Levels of S-specific and RBD-specific IgG increased by a factor of 5 after ChAdOx1 nCoV-19 and by a factor of 115 to 125 after mRNA-1273.
— NEJM (@NEJM) July 14, 2021
Vacinação heteróloga com doses da Oxford–AstraZeneca e da BioNTech/Pfizer induz aumento nos níveis de anticorpos neutralizantes em comparação a 2 doses da vacina da Oxford–AstraZeneca.
16 Jul, 2021 | 09:57hHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Relacionado: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. E Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. E RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Comentário no Twitter
Mix and match vaccines?
2 doses AZ vs AZ and then Pfizer:
"BNT162b2 induced significantly higher frequencies of spike-specific CD4+ and CD8+ T cells and, in particular, high titers of neutralizing antibodies against the B.1.1.7, B.1.351 and P.1 variants" https://t.co/53J2erWVMy pic.twitter.com/aEmqMlhEar— Eric Topol (@EricTopol) July 14, 2021
Mortes por COVID são “incrivelmente raras” entre crianças.
16 Jul, 2021 | 09:56hDeaths from COVID ‘incredibly rare’ among children – Nature
Donuts, drogas, bebidas e armas: o que os governos estão oferecendo às pessoas para que elas se vacinem contra a Covid-19 – “Programas de incentivo não visam à relação de confiança entre o público e os provedores.”
16 Jul, 2021 | 09:55hBreve revisão | O intestino na COVID-19.
16 Jul, 2021 | 09:54hThe gut in COVID-19 – Intensive Care Medicine
Comentário no Twitter
Gut & #COVID19, main findings
➡️clinical GI features
➡️pathophysiology: cytotoxic enterocyte injury, microvascular injury/thromboinfammation, non‑specifc critical illness‑related dysfunction
➡️GI dysfunction in severe #SARSCoV2 vs other critical illnesseshttps://t.co/wzzTNldInN pic.twitter.com/DnHLMsSu6v— Intens Care Med (@yourICM) July 9, 2021
Fisiopatologia da lesão renal aguda associada a COVID-19.
16 Jul, 2021 | 09:50hPathophysiology of COVID-19-associated acute kidney injury – Nature Reviews Nephrology