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Arquivos do dia: Junho 7, 2021

Estudo randomizado: Em pacientes internados com Covid-19 e D-dímero elevado, a estratégia de anticoagulação em dose plena baseada em rivaroxabam (dose plena de heparinas em pacientes instáveis) + rivaroxabam até o dia 30 não foi melhor do que a anticoagulação profilática e aumentou o risco de sangramento.

7 Jun, 2021 | 10:33h

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial – The Lancet

Relacionado: #ACC21 – [Not published yet] RCT: Among hospitalized patients with Covid-19 and elevated D-Dimer, therapeutic anticoagulation with Rivaroxaban 20 mg was not associated with improved outcomes and resulted in increased major bleeding.

 

Comentário no Twitter

 

Estudo mostra atividade reduzida de anticorpos neutralizantes, induzida pela vacina da Pfizer–BioNTech, contra as variantes de preocupação do SARS-CoV-2 B.1.617.2 (Delta) e B.1.351 (Beta).

7 Jun, 2021 | 10:31h

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2  and B.1.351 (Beta) by BNT162b2 vaccination – The Lancet

Comentário: Pfizer-BioNTech vaccine recipients have lower antibody levels targeting the Delta variant – The Francis Crick Institute

 

Comentário no Twitter (fio – clique para saber mais)

 

6 meses de vacinas contra COVID: o que 1,7 bilhão de doses ensinaram aos cientistas.

7 Jun, 2021 | 10:30h

Six months of COVID vaccines: what 1.7 billion doses have taught scientists – Nature

Ver também: Coronavirus (COVID-19) Vaccinations – Our World in Data

 

Comentário relacionado no Twitter

 

Aprovação da vacina CoronaVac pela OMS será crucial na contenção da pandemia.

7 Jun, 2021 | 10:29h

WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic – Nature

Relacionado: WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations E Brazilian town experiment shows mass vaccination can wipe out COVID-19.

Relato de caso: Tratamento bem-sucedido da trombocitopenia imune protrombótica induzida por vacina (VIPIT – vaccine-induced prothrombotic immune thrombocytopenia).

7 Jun, 2021 | 10:28h

Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) – Journal of Thrombosis and Haemostasis

Comentário: COVID-19 vaccination: Thrombosis can be prevented by prompt treatment, researchers report – Medical University of Vienna

2 novas metanálises detalham as condições neurológicas e psiquiátricas causadas pela COVID-19.

7 Jun, 2021 | 10:26h

Neurologic, psychiatric conditions common in COVID-19 – CIDRAP

Metanálise 1: Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives – Journal of Neurology, Neurosurgery & Psychiatry

Metanálise 2: Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings – BMC Infectious Diseases

Relacionado: Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions

Mais dados sobre os efeitos danosos da pandemia de COVID-19 na saúde mental de adolescentes.

7 Jun, 2021 | 10:25h

Depressive symptoms, mental wellbeing, and substance use among adolescents before and during the COVID-19 pandemic in Iceland: a longitudinal, population-based study – The Lancet Psychiatry

Comentários: A lost generation? COVID-19 and adolescent mental health – The Lancet Psychiatry E COVID-19 pandemic has had significant impact on the mental health of adolescents – Columbia University Mailman School of Public Health

 

Comentário no Twitter (fio – clique para saber mais)

 

Investigação | Covid-19: Como a indústria do tabaco aproveitou a pandemia para promover a nicotina.

7 Jun, 2021 | 10:24h

Covid 19: How harm reduction advocates and the tobacco industry capitalised on the pandemic to promote nicotine – The BMJ

Comentários: Researchers report how the tobacco and e-cigarette industry capitalized on COVID-19 to promote smoking – News Medical E Investigation discredits studies suggesting lower COVID-19 risk for smokers

Perspectiva | As estatinas poderiam fazer mais do que baixar o colesterol em pacientes com COVID-19? – “Não comece, não pare.”

7 Jun, 2021 | 10:22h

Could Statins Do More Than Lower Cholesterol in Patients With COVID-19? – JAMA

Opinião | “Os médicos têm sido culpados pelo surgimento do fungo negro na Índia, mas as diretrizes de tratamento da COVID podem ter contribuído” – Uso inadequado de antibióticos e doses mais altas de corticosteroides podem estar contribuindo para o surgimento da mucormicose e de outras coinfecções fúngicas.

7 Jun, 2021 | 10:21h

Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing – The Conversation

Ver também: Rising incidence of mucormycosis in patients with COVID-19: another challenge for India amidst the second wave? – The Lancet Respiratory Medicine

Relacionado: The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries – The Lancet E What Is ‘Black Fungus’? And Why Is It Spreading Among India’s COVID Patients? – NPR E Mucormycosis: The ‘black fungus’ maiming Covid patients in India E What is mucormycosis, the fungal infection affecting COVID patients in India? – The Conversation

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