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Vacinas

Diretriz atualizada da OMS SAGE sobre como alocar vacinas contra COVID-19 no contexto de suprimentos limitados.

2 Ago, 2021 | 17:43h

WHO SAGE Roadmap For Prioritizing Uses Of COVID-19 Vaccines In The Context Of Limited Supply – World Health Organization

O que é “breakthrough infection”? 6 questões e respostas sobre infecções por SARS-CoV-2 adquiridas após vacinação.

2 Ago, 2021 | 17:38h

What is a breakthrough infection? 6 questions answered about catching COVID-19 after vaccination – The Conversation

Vacinas contra COVID-19 diminuem a disseminação viral, mas a variante Delta é um fator desconhecido – “Estudos mostram que as vacinas reduzem a disseminação do SARS-CoV-2 em mais de 80%, mas a variante Delta está criando uma nova incerteza.”

2 Ago, 2021 | 17:36h

COVID vaccines slash viral spread – but Delta is an unknown – Nature

Dados mostram que a eficácia da vacina da Pfizer/BioNTech contra Covid cai para 84% depois de 6 meses.

2 Ago, 2021 | 17:35h

Efficacy of Pfizer/BioNTech Covid vaccine slips to 84% after six months, data show – STAT

Estudo original (preprint): Six Month Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine – medRxiv

 

Comentário no Twitter (fio – clique para saber mais)

 

[Preprint] Covid-19: intervalo mais longo entre as doses da vacina da Pfizer aumenta a resposta imune.

27 Jul, 2021 | 10:34h

Comunicado de imprensa: Longer interval between Covid-19 Pfizer vaccine doses boosts immunity – Newcastle University

Estudo original (preprint): Sustained T cell immunity, protection and boosting using extended dosing intervals of BNT162b2 mRNA vaccine

Comentários:

Commentary: Covid-19: Longer interval between Pfizer doses results in higher antibody levels, research finds – BMJ

Expert reaction to preprint from PITCH study looking at interval between two Pfizer vaccine doses, and antibody and T-cell responses – Science Media Centre

Conteúdo Relacionado:

Debate: Should we delay second vaccine doses to give one dose of the Covid-19 vaccine to more people? (vários textos sobre o tema)

Outro estudo mostra resposta imune aumentada com vacinação heteróloga Oxford-AstraZeneca/mRNA.

27 Jul, 2021 | 10:32h

Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination – Nature Medicine

Comentário: A ‘mix and match’ approach to SARS-CoV-2 vaccination – Nature Medicine

Conteúdos Relacionados:

WHO warns against mixing and matching COVID vaccines.

Germany issues world’s strongest recommendation for mixing Covid-19 vaccines.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

 

Comentário no Twitter

 

Entre receptores de transplante de rim que não tiveram resposta imune adequada a 2 doses, uma terceira dose de vacina mRNA induziu resposta sorológica em 49% dos pacientes.

26 Jul, 2021 | 10:18h

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses – JAMA

Comentário: Case Mounts for COVID Vaccine Boosters in Kidney Transplant Recipients – MedPage Today (necessário cadastro gratuito)

Relacionado:

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

[Preprint] 3rd AstraZeneca shot gives strong immunity.

 

Comentário no Twitter

 

OMS | Desigualdade vacinal prejudica a recuperação econômica global.

23 Jul, 2021 | 10:19h

Comunicado de imprensa: Vaccine inequity undermining global economic recovery – World Health Organization

Painel: Global Dashboard for Vaccine Equity

Comentários: Urgent need for COVID-19 vaccine equity – University of Oxford E COVID-19 Vaccine Inequity Undermines Global Economic Recovery  – Health Policy Watch

 

Comentário no Twitter (fio – clique para saber mais)

 

Estudo mostra que vacinas da AstraZeneca e da Pfizer são eficazes contra a variante Delta, mas são necessárias as duas doses.

22 Jul, 2021 | 13:08h

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant – New England Journal of Medicine

Comentários: Study Finds Pfizer And AstraZeneca Vaccines Effective Against The Delta Variant — As Long As You Get Both Doses – Forbes E Pfizer’s COVID-19 vaccine works very well against the Delta variant — but only after 2 doses – Insider

Relacionado: [Preprint] 2 doses of Covid vaccines (Pfizer-BioNTech or Oxford-AstraZeneca) highly effective against hospitalization from Delta variant. E Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization. E Should I get my second AstraZeneca dose? Yes, it almost doubles your protection against Delta.

 

Comentário no Twitter

 

Crianças devem tomar vacina contra COVID? O que diz a ciência.

22 Jul, 2021 | 13:05h

Should children get COVID vaccines? What the science says – Nature

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