Vacinas
[Preprint] Estudo observacional no Brasil mostrou que a efetividade ajustada da vacina da J&J foi de 50,9% contra Covid-19 sintomática, 72,9% para internações, 92,5% para admissão em UTI, 88,7% para ventilação mecânica e 90,5% para morte.
20 Out, 2021 | 12:05hVacinas da China contra a COVID foram cruciais – agora, a imunidade está diminuindo.
19 Out, 2021 | 12:49hChina’s COVID vaccines have been crucial — now immunity is waning – Nature
Conteúdos relacionados:
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Vacina da J&J contra COVID-19: FDA recomenda dose de reforço para adultos acima de 18 anos pelo menos 2 meses depois da vacinação com dose única.
18 Out, 2021 | 08:55hComunicado de imprensa: Johnson & Johnson COVID-19 Vaccine Booster Shot Unanimously Recommended for Emergency Use Authorization by U.S. FDA Advisory Committee
Comentários:
FDA panel endorses booster shot for J&J COVID-19 vaccine – Associated Press
FDA advisers recommend J&J Covid-19 vaccine boosters, talk mix and match boosters – CNN
Conteúdo relacionado: [Press release – not published yet] J&J says booster shot at two months provided 75% protection against moderate to severe COVID-19 globally and 94% of such cases in the U.S.
[Preprint] Avanço das infecções por SARS-CoV-2 em 620.000 veteranos americanos, de 1/2/2021 a 13/8/2021 – “A proteção da vacina diminuiu de 91,9% em março para 53,9% em meados de agosto.”
18 Out, 2021 | 08:51hConteúdos relacionados:
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Comentário no Twitter
New on breakthrough infections in 620,000 Veterans
"Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%"https://t.co/xonBb4aEqJ highest reduction with J&J vaccine pic.twitter.com/rbhXOREFPP— Eric Topol (@EricTopol) October 15, 2021
Oito meses depois: pesquisadores comparam as respostas imunes elicitadas por 3 vacinas contra COVID-19.
18 Out, 2021 | 08:50hComunicado de imprensa: Eight months later: Researchers compare immune responses elicited by three COVID-19 vaccines – Beth Israel Deaconess Medical Center
Estudo original: Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines – New England Journal of Medicine
Comentário no Twitter
Just published @NEJM
Neutralizing antibody levels and T cells response out to 8 months for Pfizer, Moderna and J&J vaccines https://t.co/ghAgk3Y4kR
Moderna highest antibody response; J&J while lower doesn't fall off and best CD8 T-cell response at 8 months pic.twitter.com/uANSzAylMF— Eric Topol (@EricTopol) October 15, 2021
Estudo avaliou diversos regimes heterólogos de vacinas contra o SARS-CoV-2; não há dados de eficácia, mas houve maior aumento na produção de anticorpos nos participantes 15 e 29 dias depois da dose de reforço com vacinas da Moderna e da Pfizer.
15 Out, 2021 | 16:49hHeterologous SARS-CoV-2 Booster Vaccinations: Preliminary Report – medRxiv
Comentário: Study: Mixing and Matching COVID-19 Booster Shots Is Effective, Safe – U.S. News
Comentário no Twitter
So yes, mRNA vaccines are great at generating antibodies but what does that mean? Where is the efficacy data? How come JnJ gets really great efficacy at preventing symptomatic COVID and severe disease with low antibodies? T-cells? Still much to learn. https://t.co/YwKUyogAhQ
— Daniel Griffin MD PhD (@DanielGriffinMD) October 13, 2021
Perspectiva | Tentativa de bloquear a transmissão do SARS-CoV-2 com vacinas intranasais.
15 Out, 2021 | 16:45hTrying to Block SARS-CoV-2 Transmission With Intranasal Vaccines – JAMA
Painel do FDA libera doses de reforço da vacina da Moderna contra COVID para grupos de risco.
15 Out, 2021 | 16:44hFDA panel green-lights Moderna COVID boosters for risk groups – CIDRAP
Editorial | Tratamentos e vacinas contra Covid-19 devem ser avaliados na gravidez.
15 Out, 2021 | 16:42hCovid-19 treatments and vaccines must be evaluated in pregnancy – The BMJ
Conteúdos relacionados:
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Comentário no Twitter
Inconsistent messaging from authorities, driven by lack of trial data, has increased covid-19 vaccine hesitancy among pregnant women@DrAllyah and colleagues argue that pregnant women should be included in drug and vaccine development from the outsethttps://t.co/P3v1ouk8tQ
— The BMJ (@bmj_latest) October 14, 2021
Estudo de coorte: gestantes vacinadas tiveram risco de Covid-19 severo ou crítico 90% menor do que gestantes não vacinadas.
15 Out, 2021 | 16:41hConteúdos relacionados:
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Comentário no Twitter (fio – clique para saber mais)
First dataset I have seen for vaccine efficacy in pregnant persons during #Delta era. Impressive aOR for both severe illness (0.11) and infection positivity in general (0.31)! #GetVaccinatedNow 🤰🏻💉 https://t.co/VhBHyeOWjz
— Lauren Hassen, MD MPH (@ljhassen) October 14, 2021