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Resultados de longo prazo de um estudo randomizado | Vasopressina e metilprednisolona não melhoraram os desfechos em pacientes com parada cardíaca em ambiente hospitalar.

29 Ago, 2022 | 16:40h

Effect of vasopressin and methylprednisolone vs. placebo on long-term outcomes in patients with in-hospital cardiac arrest a randomized clinical trial – Resuscitation

Estudo original: RCT: Vasopressin + Methylprednisolone increase the likelihood of return of spontaneous circulation compared to placebo in patients with in-hospital cardiac arrest.

 

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Diretriz de posicionamento | Doença renal crônica como fator de risco cardiovascular na prática clínica.

29 Ago, 2022 | 16:39h

Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association – European Journal of Preventive Cardiology (PDF)

 

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Diretrizes para avaliação clínica e manejo do implante coclear em adultos com surdez unilateral.

29 Ago, 2022 | 16:37h

American Cochlear Implant Alliance Task Force Guidelines for Clinical Assessment and Management of Adult Cochlear Implantation for Single-Sided Deafness – Ear and Hearing

 

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Diretrizes de prática clínica para tratamento da dermatite atópica.

29 Ago, 2022 | 16:36h

English Version of Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021 – The Journal of Dermatology

 

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M-A de estudos randomizados | Risco de eventos adversos cutâneos em pacientes oncológicos tratados com inibidores da fosfatidilinositol-3-quinase.

29 Ago, 2022 | 16:35h

Risk of cutaneous adverse events in cancer patients treated with phosphatidylinositol-3-kinase inhibitors: A systematic review and meta-analysis of randomized controlled trials – Cancer Medicine

 

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Análise secundária de um estudo randomizado | Controle rítmico precoce em pacientes com fibrilação atrial e comorbidades.

29 Ago, 2022 | 16:34h

Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden – Circulation

 

Comentário no Twitter

#OriginalResearch: In #EAST_AFNET4, substudy of patients w/ CHA2DS2VASC4 >=4 had decreased composite efficacy outcome of lower CV death, CVA or HF/ACS hospitalization w/ rhythm control, but not in patients with lower como… @AndreasRillig @AndreasMetzner7 https://t.co/izES0WodVQ pic.twitter.com/DVyfWsUsOx

— Circulation (@CircAHA) August 17, 2022

 

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Revisão sistemática | Carga anticolinérgica para predição de declínio cognitivo ou sintomas neuropsiquiátricos em idosos com comprometimento cognitivo leve ou demência.

29 Ago, 2022 | 16:33h

Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia – Cochrane Library

Resumo: The impact of cumulative medications with anticholinergic effects on future adverse clinical outcomes in people with dementia – Cochrane Library

Conteúdos relacionados:

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Commonly-prescribed drugs and dementia: should we be worried? – Evidently Cochrane

Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome – Cochrane Library

Anticholinergic drugs and dementia: time for transparency in the face of uncertainty – Cochrane Library

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study – JAMA Internal Medicine

How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative

Anticholinergic drugs and risk of dementia: case-control study – The BMJ

 

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Tratamento da osteoartrite da mão: de uma diretriz médica norte-americana baseada em evidências para uma abordagem europeia centrada no paciente.

29 Ago, 2022 | 16:32h

Management of hand osteoarthritis: from an US evidence-based medicine guideline to a European patient-centric approach – Aging Clinical and Experimental Research

Conteúdos relacionados:

Erosive hand osteoarthritis: latest findings and outlook – Nature Reviews Rheumatology

Efficacy of corticosteroids for hand osteoarthritis – a systematic review and meta-analysis of randomized controlled trials – BMC Musculoskeletal Disorders

ACR Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

#ACR19 – Randomized Trial: Low-Dose Corticosteroids for Short Periods Effective and Safe for Hand Osteoarthritis

#ACR19 – [Not Published Yet] Randomized Trial: Methotrexate May Reduce Joint Damage Progression in Erosive Hand Osteoarthritis

Research: Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis

 

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Podcast | Atualização USPSTF: aspirina para prevenção primária de doença cardiovascular.

29 Ago, 2022 | 16:30h

#347 USPSTF Update: Aspirin for Primary Prevention of CVD – The Curbsiders

Diretriz relacionada: USPSTF Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease.

Estudos randomizados relacionados:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Metanálise relacionada:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Opiniões relacionadas:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

 

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Podcast | Miosite e miopatia.

29 Ago, 2022 | 16:29h

#348 Myositis and Myopathy, LIVE! – The Curbsiders

 

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